Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo

by Jothilingam Sivapackiam, Fuyi Liao, Dequan Zhou, Kooresh I. Shoghi, Robert J. Gropler, Andrew E. Gelman, Vijay Sharma
Published 2020-10-01

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

by Roberta Peruzzo, Andrea Mattarei, Michele Azzolini, Katrin Anne Becker-Flegler, Matteo Romio, Giovanni Rigoni, Andrea Carrer, Lucia Biasutto, Sofia Parrasia, Stephanie Kadow, Antonella Managò, Andrea Urbani, Andrea Rossa, Gianpietro Semenzato, Maria Eugenia Soriano, Livio Trentin, Syed Ahmad, Michael Edwards, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Luigi Leanza, Ildikò Szabò
Published 2020-10-01

Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein...

by Richard Kehm, Markus Jähnert, Stefanie Deubel, Tanina Flore, Jeannette König, Tobias Jung, Mandy Stadion, Wenke Jonas, Annette Schürmann, Tilman Grune, Annika Höhn
Published 2020-10-01

High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans

by Kyohei Koseki, Yukina Maekawa, Tomohiro Bito, Yukinori Yabuta, Fumio Watanabe
Published 2020-10-01

Rapid, redox-mediated mechanical susceptibility of the cortical microtubule lattice in skeletal muscle

by D'anna M. Nelson, Elizabeth K. Fasbender, Margurite C. Jakubiak, Angus Lindsay, Dawn A. Lowe, James M. Ervasti
Published 2020-10-01

Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes

by Su-Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Seung-Soon Im, Jae-Hoon Bae, Dae-Kyu Song
Published 2020-10-01

Nrf2: A unifying transcription factor in the pathogenesis of Fuchs’ endothelial corneal dystrophy

by Matthew Lovatt, Viridiana Kocaba, Dawn Jing Hui Neo, Yu Qiang Soh, Jodhbir S. Mehta
Published 2020-10-01

Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway

by Can Hu, Xin Zhang, Peng Song, Yu-Pei Yuan, Chun-Yan Kong, Hai-Ming Wu, Si-Chi Xu, Zhen-Guo Ma, Qi-Zhu Tang
Published 2020-10-01

SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy

by Sudha Sharma, Susmita Bhattarai, Hosne Ara, Grace Sun, Daret K. St Clair, Md Shenuarin Bhuiyan, Christopher Kevil, Megan N. Watts, Paari Dominic, Takahiko Shimizu, Kevin J. McCarthy, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Published 2020-10-01

Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance

by Cheng Wang, Yuelin Chao, Wenjing Xu, Zhaoyu Liu, Huan Wang, Kai Huang
Published 2020-10-01

Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner

by Yu Yan, Xun Wu, Pengcheng Wang, Songyang Zhang, Lulu Sun, Yang Zhao, GuangYi Zeng, Bo Liu, Guoheng Xu, Huiying Liu, Lei Wang, Xian Wang, Changtao Jiang
Published 2020-10-01

JNK signalling regulates antioxidant responses in neurons

by Chris Ugbode, Nathan Garnham, Laura Fort-Aznar, Gareth J.O. Evans, Sangeeta Chawla, Sean T. Sweeney
Published 2020-10-01

Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degenerat...

by Parameswaran G. Sreekumar, Ram Kannan
Published 2020-10-01

Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species

by Natividad Blasco, Aida Beà, Gisel Barés, Cristina Girón, Raúl Navaridas, Andrea Irazoki, Guillermo López-Lluch, Antonio Zorzano, Xavier Dolcet, Marta Llovera, Daniel Sanchis
Published 2020-10-01

The fear-defense system, emotions, and oxidative stress

by Jasmin Ghaemi Kerahrodi, Matthias Michal
Published 2020-10-01

Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism

by Xin Nie, Weiqi Tang, Zihui Zhang, Chunmiao Yang, Lei Qian, Xinya Xie, Erjiao Qiang, Jingyang Zhao, Wenfei Zhao, Lei Xiao, Nanping Wang
Published 2020-10-01

Nogo-B is a key mediator of hepatic ischemia and reperfusion injury

by Jianhua Rao, Feng Cheng, Haoming Zhou, Wenjie Yang, Jiannan Qiu, Chao Yang, Xuehao Ni, Shikun Yang, Yongxiang Xia, Xiongxiong Pan, Feng Zhang, Ling Lu, Xuehao Wang
Published 2020-10-01

Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration

by Yoko Ozawa, M.D., Ph.D.
Published 2020-10-01

NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation

by Emily Stenke, Gabriella Aviello, Ashish Singh, Sean Martin, Des Winter, Brian Sweeney, Michael McDermott, Billy Bourke, Seamus Hussey, Ulla G. Knaus
Published 2020-10-01

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

by Seung-Hwan Jung, Wonseok Lee, Seung-Hyun Park, Kang-Yo Lee, You-Jin Choi, Soohee Choi, Dongmin Kang, Sinri Kim, Tong-Shin Chang, Soon-Sun Hong, Byung-Hoon Lee
Published 2020-10-01