single nucleotide polymorphism 191 human 161 Humans 125 Polymorphism, Single Nucleotide 120 genetics 108 Article 98 female 80 controlled study 76 genotype 74 male 74 adult 72 Female 59 genome-wide association study 58 Male 54 genetic association 48 major clinical study 48 Genome-Wide Association Study 45 gene frequency 45 Genetic Predisposition to Disease 44 genetic predisposition 44 genetic variability 38 middle aged 38 allele 36 phenotype 36 Adult 35 case control study 32 Middle Aged 31 gene 29 article 28 Case-Control Studies 26