Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells

by Caihong Zhou, Qi Shen, Jinglun Xue, Chaoneng Ji, Jinzhong Chen
Published 2013-02-01

The Human Tyrosyl-DNA Phosphodiesterase 1 (hTdp1) Inhibitor NSC120686 as an Exploratory Tool to Investigate Plant Tdp1 Genes

by Anca Macovei, Andrea Pagano, Maria Elisa Sabatini, Sofia Grandi, Alma Balestrazzi
Published 2018-03-01

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

by Alexandra L. Zakharenko, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Georgy A. Ivanov, Vladimir E. Oslovsky, Ekaterina S. Ilina, Irina A. Chernyshova, Olga I. Lavrik, Sergey N. Mikhailov
Published 2020-08-01

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

by Anastasia O. Komarova, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Irina V. Kulikova, Vladimir E. Oslovsky, Olga D. Zakharova, Alexandra L. Zakharenko, Sergey N. Mikhailov, Olga I. Lavrik
Published 2018-01-01

Ultrastructural and Molecular Analyses Reveal Enhanced Nucleolar Activity in Medicago truncatula Cells Overexpressing the MtTdp2α Gene

by Anca Macovei, Matteo Faè, Marco Biggiogera, Susana de Sousa Araújo, Daniela Carbonera, Alma Balestrazzi
Published 2018-05-01

Effect of Pterostilbene, a Natural Derivative of Resveratrol, in the Treatment of Colorectal Cancer through Top1/Tdp1-Mediated DNA Repair Pathway

by Yutian Zhang, Ying Li, Changcheng Sun, Xiang Chen, Luyao Han, Tingqiang Wang, Jinfeng Liu, Xijing Chen, Di Zhao
Published 2021-08-01

Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining

by Giacomo Mutti, Alessandro Raveane, Andrea Pagano, Francesco Bertolini, Ornella Semino, Alma Balestrazzi, Anca Macovei
Published 2020-12-01

The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses

by Maria Elisa Sabatini, Andrea Pagano, Susana Araùjo, Alma Balestrazzi, Anca Macovei
Published 2017-11-01

A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors

by Ann-Katrine Jakobsen, Josephine Geertsen Keller, María Gonzalez, Endika Martin-Encinas, Francisco Palacios, Concepcion Alonso, Birgitta Ruth Knudsen, Magnus Stougaard
Published 2021-07-01

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

by Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2021-07-01

Exploring microRNA Signatures of DNA Damage Response Using an Innovative System of Genotoxic Stress in Medicago truncatula Seedlings

by Carla Gualtieri, Maraeva Gianella, Andrea Pagano, Tiziano Cadeddu, Susana Araújo, Susana Araújo, Alma Balestrazzi, Anca Macovei
Published 2021-03-01

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

by Irina V. Il’ina, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Alexander Yu. Sidorenko, Nikolay S. Li-Zhulanov, Dina V. Korchagina, Raina Chand, Daniel M. Ayine-Tora, Arina A. Chepanova, Olga D. Zakharova, Ekaterina S. Ilina, Jóhannes Reynisson, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2020-07-01

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols

by Nadezhda Dyrkheeva, Rashid Anarbaev, Rashid Anarbaev, Natalia Lebedeva, Maxim Kuprushkin, Alexandra Kuznetsova, Nikita Kuznetsov, Nadejda Rechkunova, Olga Lavrik, Olga Lavrik
Published 2020-12-01

Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level

by Joanna Proszek, Amit Roy, Ann-Katrine Jakobsen, Rikke Frøhlich, Birgitta R. Knudsen, Magnus Stougaard
Published 2014-01-01

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

by Aleksander S. Filimonov, Arina A. Chepanova, Olga A. Luzina, Alexandra L. Zakharenko, Olga D. Zakharova, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Maxim S. Kuprushkin, Anton V. Kolotaev, Derenik S. Khachatryan, Jinal Patel, Ivanhoe K.H. Leung, Raina Chand, Daniel M. Ayine-Tora, Johannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Published 2019-10-01

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes

by Ka Cheong Lee, Rebecca L. Swan, Zbyslaw Sondka, Kay Padget, Ian G. Cowell, Caroline A. Austin
Published 2018-07-01

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site

by Natalia A. Lebedeva, Nadejda I. Rechkunova, Anton V. Endutkin, Olga I. Lavrik, Olga I. Lavrik
Published 2021-01-01

Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation

by Autumn C. Holmes, Guido Zagnoli-Vieira, Keith W. Caldecott, Bert L. Semler
Published 2020-01-01