Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors

by Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Dieter Glebe, Karl-Heinz Baringhaus, Joachim Geyer
Published 2021-04-01

Biliary secretion and excretion in health and disease: Current concepts

by Alan F Hofmann
Published 2007-01-01

Mechanisms for the intestinal absorption of bile acids

by John M. Dietschy
Published 1968-05-01

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

by Alan F. Hofmann, Lee R. Hagey
Published 2014-08-01

Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Functi...

by Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer
Published 2021-06-01

Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7α-hydroxylase in rabbits fed cholesterol

by Guorong Xu, Gerald Salen, Benjamin L. Shneider, M. Ananthanarayanan, Sarah Shefer, Lin Ma, Ashok Batta, Lien B. Nguyen, Josephine J. Lingutla, G. Stephen Tint, Mark Pcolinsky, Frederick J. Suchy
Published 2001-09-01

Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor

by Xiulong Song, Yuan Chen, Leila Valanejad, Rajani Kaimal, Bingfang Yan, Matthew Stoner, Ruitang Deng
Published 2013-11-01

Transcriptome Profiling of Placenta through Pregnancy Reveals Dysregulation of Bile Acids Transport and Detoxification Function

by Peng Wang, Yumo Song, Heju Zhong, Sen Lin, Xiaoling Zhang, Jian Li, Lianqiang Che, Bin Feng, Yan Lin, Shengyu Xu, Yong Zhuo, De Wu, Douglas G. Burrin, Zhengfeng Fang
Published 2019-08-01

Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids

by Zhe Zhang, Hongxiang Li, Guangrui Xu, Ping Yao
Published 2018-01-01

Utilizing in vitro transporter data in IVIVE-PBPK: an overview

by Pankajini Mallick
Published 2017-12-01

Hyperglycemia exacerbates dyslipidemia-induced changes in uptake, synthesis, and transporters of bile acids in rats: Assessment of restorative potentials of ALA and EPA + DHA

by Pooja Acharya, Lalitha Nanjaiah, Sridevi Annapurna Singh, Ramaprasad Ravichandra Talahalli
Published 2019-03-01

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

by Grant Generaux, Vinal V. Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Keith Riccardi, Li Di, Brett A. Howell, Scott Q. Siler, Paul B. Watkins, Hugh A. Barton, Michael D. Aleo, Lisl K. M. Shoda
Published 2019-12-01

Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative–lipid complex

by Saurav Kumar Jha, Hee-Soo Han, Laxman Subedi, Rudra Pangeni, Jee Young Chung, Seho Kweon, Jeong Uk Choi, Youngro Byun, Yong-Hee Kim, Jin Woo Park
Published 2020-01-01

Improvements in the Oral Absorption and Anticancer Efficacy of an Oxaliplatin-Loaded Solid Formulation: Pharmacokinetic Properties in Rats and Nonhuman Primates and the Effects of...

by Pangeni R, Subedi L, Jha SK, Kweon S, Kang SH, Chang KY, Choi JU, Byun Y, Park JW
Published 2020-10-01

Repeated Oral Administration of Oleanolic Acid Produces Cholestatic Liver Injury in Mice

by Yasha Xu, Yuan-Fu Lu, Xiao-Li Wan, Jie Liu
Published 2013-03-01

Cystic Fibrosis Related Liver Disease—Another Black Box in Hepatology

by Katharina Staufer, Emina Halilbasic, Michael Trauner, Lili Kazemi-Shirazi
Published 2014-08-01

Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis

by Hana Lastuvkova, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Milos Hroch, Jaroslav Mokry, Hana Faistova, Zuzana Nova, Radomír Hyspler, Ivone Cristina Igreja Sa, Petr Nachtigal, Alzbeta Stefela, Petr Pavek, Stanislav Micuda
Published 2021-06-01

Atorvastatin alters the expression of genes related to bile acid metabolism and circadian clock in livers of mice

by Wen-Kai Li, Huan Li, Yuan-Fu Lu, Ying-Ying Li, Zidong Donna Fu, Jie Liu
Published 2017-05-01

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice

by Sandra K. Erickson, Steven R. Lear, Sean Deane, Sandrine Dubrac, Sandra L. Huling, Lien Nguyen, Jaya S. Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Benjamin Shneider, Ephraim Sehayek, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Fredrick J. Suchy, Ashok K. Batta, Gerald Salen
Published 2003-05-01

Withaferin-A down-regulate enterohepatic circulation of bile acids: An insight from a hyperlipidemic rat model

by Pooja Acharya, Parvati Huded, Sadashivaiah Bettadahalli, Mehrdad Zarei, Vinayak Uppin, Nayana Venugopal, Ramaprasad Ravichandra Talahalli
Published 2020-12-01