human 240 Humans 190 cardiovascular disease 178 female 166 male 150 Article 137 adult 128 Female 115 Male 98 Cardiovascular Diseases 94 major clinical study 94 middle aged 94 controlled study 90 aged 88 Middle Aged 76 risk factor 68 Aged 62 Cardiovascular disease 60 Adult 59 cohort analysis 56 Risk Factors 55 hypertension 43 cardiovascular risk 42 follow up 40 complication 39 mortality 39 cross-sectional study 37 diabetes mellitus 35 prospective study 34 metabolism 33