human 68 Article 48 female 48 male 48 Humans 44 major clinical study 39 adult 38 aged 33 all cause mortality 33 cause of death 29 mortality 29 Female 26 Male 26 controlled study 26 cohort analysis 24 middle aged 24 follow up 22 Middle Aged 20 Adult 17 retrospective study 17 Aged 16 cardiovascular disease 16 hospitalization 14 risk factor 14 mortality rate 13 prospective study 13 Cause of Death 11 Mortality 11 cerebrovascular accident 11 Retrospective Studies 10