human 206 comorbidity 189 female 169 male 166 Article 148 Humans 146 adult 130 major clinical study 116 Female 104 controlled study 102 Male 99 aged 86 middle aged 84 Comorbidity 72 Middle Aged 61 Aged 57 cohort analysis 57 retrospective study 57 Adult 56 risk factor 50 adolescent 37 follow up 37 disease severity 36 Adolescent 34 United States 34 child 34 Retrospective Studies 33 prevalence 33 diabetes mellitus 31 complication 30