human 168 Humans 142 metabolism 107 Article 104 cytokine 98 controlled study 96 male 89 Cytokines 86 female 85 Animals 73 inflammation 70 animal 67 nonhuman 65 Female 60 Male 60 mouse 59 tumor necrosis factor 56 interleukin 6 54 genetics 52 adult 50 Mice 48 Inflammation 45 pathology 45 interleukin 1beta 40 animal experiment 37 immunology 37 unclassified drug 37 major clinical study 35 animal model 33 middle aged 31