down regulation 133 Article 113 controlled study 104 human 100 upregulation 82 unclassified drug 72 Humans 70 male 66 female 64 genetics 63 metabolism 58 nonhuman 54 gene expression 50 adult 49 human cell 48 protein expression 43 Female 40 gene expression regulation 40 Male 37 human tissue 36 animal experiment 35 pathology 32 animal model 31 in vitro study 30 signal transduction 29 cell proliferation 27 real time polymerase chain reaction 27 Animals 26 Cell Line, Tumor 26 Western blotting 26