Article 400 human 390 controlled study 339 Humans 323 metabolism 266 nonhuman 254 male 211 unclassified drug 184 enzyme activity 175 female 171 genetics 150 Animals 146 chemistry 146 enzyme linked immunosorbent assay 140 animal 138 Male 137 adult 127 Female 120 Enzymes 108 TP Chemical technology 104 animal experiment 97 drug effect 81 middle aged 80 major clinical study 78 mouse 77 gene expression 76 human cell 76 rat 76 Middle Aged 74 protein expression 74