gene editing 12 human Humans 8 Article 7 CRISPR Cas system 7 Gene Editing 7 genetics 7 CRISPR-Cas Systems 6 nonhuman 5 Animals 4 animal 4 clustered regularly interspaced short palindromic repeat 4 CRISPR-CAS9 system 3 DNA sequence 3 RNA, Guide 3 controlled study 3 gene function 3 gene therapy 3 genome editing 3 guide RNA 3 metabolism 3 CRISPR-Cas9 2 CRISPR/Cas9 2 Clustered Regularly Interspaced Short Palindromic Repeats 2 DNA extraction 2 Learning 2 RNA sequence 2 Sanger sequencing 2 Streptococcus pyogenes 2 bioinformatics 2