gene silencing 29 Article 23 genetics 23 controlled study 21 human 21 metabolism 19 Humans 17 human cell 17 unclassified drug 16 protein expression 14 gene expression regulation 12 nonhuman 12 pathology 11 upregulation 11 gene expression 10 male 10 apoptosis 9 female 9 Western blotting 8 cell proliferation 8 down regulation 8 Gene Expression Regulation, Neoplastic 7 RNA interference 7 in vitro study 7 protein function 7 signal transduction 7 small interfering RNA 7 Animals 6 Apoptosis 6 Cell Proliferation 6