human 37 Humans 32 Article 31 female 26 Controllers 23 adult 23 controlled study 23 male 23 Closed-loop 18 genetics 14 Adult 13 Closed loop systems 13 insulin 13 Diabetes Mellitus, Type 1 12 Hypoglycemic Agents 12 Insulin 12 Insulin Infusion Systems 12 antidiabetic agent 12 glucose blood level 12 insulin dependent diabetes mellitus 12 insulin infusion 12 metabolism 12 middle aged 12 procedures 12 Blood Glucose 11 glucose 11 Closed-loop control 10 Female 10 major clinical study 10 Animals 9