biological marker human 47 receiver operating characteristic 45 Article 42 Humans 39 Biomarkers 36 controlled study 36 female 36 adult 33 male 32 major clinical study 29 Female 27 Male 23 sensitivity and specificity 23 blood 22 ROC Curve 20 middle aged 20 Middle Aged 19 diagnostic test accuracy study 17 Adult 16 Case-Control Studies 15 case control study 15 aged 14 metabolism 13 Aged 12 Prognosis 12 area under the curve 12 prognosis 12 clinical article 11 unclassified drug 11