human 148 major clinical study Article 134 female 132 receiver operating characteristic 131 adult 125 male 123 controlled study 121 Humans 118 Female 88 Male 81 middle aged 81 Middle Aged 72 sensitivity and specificity 70 aged 59 diagnostic test accuracy study 58 ROC Curve 48 blood 48 Adult 44 Aged 39 area under the curve 38 prognosis 38 pathology 33 risk factor 33 case control study 32 Case-Control Studies 31 Prognosis 31 predictive value 31 retrospective study 31 unclassified drug 31