controlled study Article 317 human 311 Humans 223 female 218 male 215 sensitivity and specificity 204 adult 189 major clinical study 170 Female 110 diagnostic test accuracy study 110 Male 107 middle aged 106 receiver operating characteristic 89 Middle Aged 82 nonhuman 82 Adult 75 aged 73 procedures 70 sensitivity analysis 70 unclassified drug 55 blood 52 clinical article 47 cohort analysis 47 diagnostic accuracy 46 predictive value 46 pathology 45 genetics 41 Sensitivity and Specificity 40 diagnostic imaging 39