receiver operating characteristic sensitivity and specificity 109 human 108 Article 106 controlled study 89 female 86 Humans 85 adult 80 male 78 major clinical study 71 diagnostic test accuracy study 65 Female 49 middle aged 48 Male 43 Middle Aged 40 ROC Curve 38 aged 34 area under the curve 31 blood 29 predictive value 29 procedures 28 diagnostic accuracy 27 diagnostic value 27 pathology 27 Adult 25 prognosis 25 human tissue 24 biological marker 23 machine learning 23 unclassified drug 22