signal transduction human 154 Article 130 Humans 124 Signal Transduction 109 metabolism 108 controlled study 97 nonhuman 86 genetics 84 Animals 70 animal 69 male 56 protein expression 48 animal experiment 45 female 45 mouse 42 upregulation 41 unclassified drug 40 adult 39 human cell 38 drug effect 37 gene expression 36 pathology 36 physiology 33 animal model 32 down regulation 29 Male 28 gene expression regulation 28 Mice 27 Female 26