human 26 Humans 20 genetics 17 somatic mutation 17 Mutation 14 Article 13 female 12 Female 10 male 10 mutation 10 adult 9 controlled study 9 Male 8 gene mutation 7 gene frequency 6 high throughput sequencing 6 major clinical study 6 middle aged 6 nonhuman 6 pathology 6 whole exome sequencing 6 Neoplasms 5 article 5 human tissue 5 neoplasm 5 DNA sequence 4 High-Throughput Nucleotide Sequencing 4 Middle Aged 4 aged 4 clinical article 4