controlled study male 162 human 155 female 151 Article 138 adult 136 Humans 120 anxiety 99 major clinical study 92 Male 91 Female 88 depression 70 Adult 69 anxiety disorder 59 psychology 56 Anxiety 55 adolescent 49 middle aged 43 questionnaire 42 young adult 41 Adolescent 40 Young Adult 37 Middle Aged 36 nonhuman 35 article 34 randomized controlled trial 33 animal experiment 31 child 31 priority journal 31 aged 28