male Article 112 human 107 controlled study 102 female 100 Humans 94 genetics 91 Male 90 adult 82 gene expression 71 Female 69 metabolism 64 unclassified drug 61 gene expression regulation 57 upregulation 53 middle aged 51 down regulation 50 major clinical study 49 nonhuman 49 Middle Aged 48 pathology 48 human tissue 42 protein expression 40 human cell 38 Animals 37 animal experiment 37 Gene Expression Regulation, Neoplastic 36 animal 36 aged 35 animal model 32