upregulation Article 96 controlled study 84 human 80 genetics 67 Humans 66 down regulation 63 unclassified drug 57 metabolism 55 gene expression 54 male 53 gene expression regulation 48 female 47 nonhuman 47 human cell 41 adult 40 protein expression 38 pathology 37 Male 34 Female 33 Gene Expression Regulation, Neoplastic 32 real time polymerase chain reaction 32 cell proliferation 31 human tissue 31 signal transduction 30 animal experiment 29 Western blotting 28 animal model 27 Up-Regulation 26 Animals 25