controlled study human 217 male 192 Article 183 female 172 adult 164 Humans 151 Male 100 major clinical study 98 Female 88 nonhuman 74 article 72 middle aged 66 Adult 63 aged 57 Middle Aged 55 procedures 46 animal experiment 40 clinical article 39 randomized controlled trial 38 diagnostic imaging 36 human experiment 35 Animals 34 unclassified drug 34 Aged 33 animal 33 nuclear magnetic resonance imaging 33 young adult 33 adolescent 32 physiology 32