A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose

by James W Dear, Mei Li Ng, D. Nicholas Bateman, Pakkiri Leroy Sivappiragasam, Hyungwon Choi, Benjamin Bing Jie Khoo, Baharudin Ibrahim, Chester Lee Drum
Published 2021-07-01

Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.

by David M Rissin, Barbara López-Longarela, Salvatore Pernagallo, Hugh Ilyine, A D Bastiaan Vliegenthart, James W Dear, Juan J Díaz-Mochón, David C Duffy
Published 2017-01-01

Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracet...

by Emma E. Morrison, Katherine Oatey, Bernadette Gallagher, Julia Grahamslaw, Rachel O'Brien, Polly Black, Wilna Oosthuyzen, Robert J. Lee, Christopher J. Weir, Dennis Henriksen, James W. Dear
Published 2019-08-01

Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

by Danny Laurent, Fiona Semple, Philip J. Starkey Lewis, Elaine Rose, Holly A. Black, Jennifer Coe, Stuart J. Forbes, Mark J. Arends, James W. Dear, Timothy J. Aitman
Published 2020-04-01

Urinary Extracellular Vesicle Protein Profiling and Endogenous Lithium Clearance Support Excessive Renal Sodium Wasting and Water Reabsorption in Thiazide-Induced Hyponatremia

by Sarath K. Channavajjhala, Roger Bramley, Theresa Peltz, Wilna Oosthuyzen, Wenjing Jia, Sue Kinnear, Barry Sampson, Nick Martin, Ian P. Hall, Matthew A. Bailey, James W. Dear, Mark Glover
Published 2019-01-01

Circulating argonaute-bound microRNA-126 reports vascular dysfunction and treatment response in acute and chronic kidney disease

by Kathleen M. Scullion, A. D. Bastiaan Vliegenthart, Laura Rivoli, Wilna Oosthuyzen, Tariq E. Farrah, Alicja Czopek, David J. Webb, Robert W. Hunter, Matthew A. Bailey, Neeraj Dhaun, James W. Dear
Published 2021-01-01

Activated neutrophil fluorescent imaging technique for human lungs

by Thomas H. Craven, Tashfeen Walton, Ahsan R. Akram, Emma Scholefield, Neil McDonald, Adam D.L. Marshall, Duncan C. Humphries, Bethany Mills, Thane A. Campbell, Annya Bruce, Joanne Mair, James W. Dear, David E. Newby, Adam T. Hill, Timothy S. Walsh, Chris Haslett, Kevin Dhaliwal
Published 2021-01-01

Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose

by Janice M. Pettie, Thomas M. Caparrotta, Robert W. Hunter, Emma E. Morrison, David M. Wood, Paul I. Dargan, Ruben H. Thanacoody, Simon H.L. Thomas, Muhammad E.M.O. Elamin, Ben Francis, David J. Webb, Euan A. Sandilands, Michael Eddleston, James W. Dear
Published 2019-05-01

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

by Olivia Matthews, Emma E. Morrison, John D. Tranter, Philip Starkey Lewis, Iqbal S. Toor, Abhishek Srivastava, Rebecca Sargeant, Helen Rollison, Kylie P. Matchett, Timothy J. Kendall, Gillian A. Gray, Chris Goldring, Kevin Park, Laura Denby, Neeraj Dhaun, Matthew A. Bailey, Neil C. Henderson, Dominic Williams, James W. Dear
Published 2020-12-01

Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure

by Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Published 2021-06-01

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

by Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton, James W. Dear, Juan M. Falcón‐Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge Mertens, Luca Musante, Eline Oeyen, Maija Puhka, Martin E. vanRoyen, Catherine Sánchez, Carolina Soekmadji, Visith Thongboonkerd, Volkert vanSteijn, Gerald Verhaegh, Jason P. Webber, Kenneth Witwer, Peter S.T. Yuen, Lei Zheng, Alicia Llorente, Elena S. Martens‐Uzunova
Published 2021-05-01