The Complexities of Engineering Human Stem Cell-Derived Therapeutics

by David C. Hay, James A. Ross, Ronnie Gallagher, Pierre Bagnaninchi
Published 2010-01-01

Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction

by Ruchi Sharma, Sebastian Greenhough, Claire N. Medine, David C. Hay
Published 2010-01-01

Human PSC-Derived Hepatocytes Express Low Levels of Viral Pathogen Recognition Receptors, but Are Capable of Mounting an Effective Innate Immune Response

by Lena Fischer, Baltasar Lucendo-Villarin, David C. Hay, Cliona O’Farrelly
Published 2020-05-01

Protocol for automated production of human stem cell derived liver spheres

by Jose Meseguer-Ripolles, Alvile Kasarinaite, Baltasar Lucendo-Villarin, David C. Hay
Published 2021-06-01

Modeling Human Liver Biology Using Stem Cell-Derived Hepatocytes

by Arvind H. Patel, David C. Hay, Sarah L. Farnworth, Pingnan Sun, Xiaoling Zhou
Published 2013-11-01

Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes

by Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Amanda J. Drake, David C. Hay
Published 2021-06-01

Mathematical modelling of oxygen gradients in stem cell-derived liver tissue.

by Joseph A Leedale, Baltasar Lucendo-Villarin, Jose Meseguer-Ripolles, Alvile Kasarinaite, Steven D Webb, David C Hay
Published 2021-01-01

Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs

by Dagmara Szkolnicka, Baltasar Lucendo-Villarin, Joanna K. Moore, Kenneth J. Simpson, Stuart J. Forbes, David C. Hay
Published 2016-06-01

Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived Hepatocytes

by Xiaoling Zhou, Pingnan Sun, Baltasar Lucendo-Villarin, Allan G.N. Angus, Dagmara Szkolnicka, Kate Cameron, Sarah L. Farnworth, Arvind H. Patel, David C. Hay
Published 2014-07-01

Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells.

by Diego Calabrese, Guglielmo Roma, Sebastian Bergling, Walter Carbone, Valentina Mele, Sandro Nuciforo, Isabel Fofana, Benedetta Campana, Dagmara Szkolnicka, David C Hay, Jan Tchorz, Tewis Bouwmeester, Stefan Wieland, Markus H Heim
Published 2019-01-01

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes

by Kate Cameron, Rosanne Tan, Wolfgang Schmidt-Heck, Gisela Campos, Marcus J. Lyall, Yu Wang, Baltasar Lucendo-Villarin, Dagmara Szkolnicka, Nicola Bates, Susan J. Kimber, Jan G. Hengstler, Patricio Godoy, Stuart J. Forbes, David C. Hay
Published 2015-12-01

Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor

by Yimeng Gao, Xiaoran Zhang, Ludi Zhang, Jin Cen, Xuan Ni, Xiaoying Liao, Chenxi Yang, Ying Li, Xiaotao Chen, Zhao Zhang, Yajing Shu, Xin Cheng, David C. Hay, Dongmei Lai, Guoyu Pan, Gang Wei, Lijian Hui
Published 2017-12-01

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

by Yu Wang, Michael H. Tatham, Wolfgang Schmidt-Heck, Carolyn Swann, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Tilo Kunath, Timothy R. Rudd, Andrew J.H. Smith, Jan G. Hengstler, Patricio Godoy, Ronald T. Hay, David C. Hay
Published 2019-06-01

A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis

by Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Sara Wernig-Zorc, John P. Thomson, Roderick N. Carter, Marcus J. Lyall, Paul D. Walker, Alpesh Thakker, Richard R. Meehan, Gareth G. Lavery, Nicholas M. Morton, Christian Ludwig, Daniel A. Tennant, David C. Hay, Amanda J. Drake
Published 2021-01-01

Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure

by Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Published 2021-06-01