Atypical Reactive Center Kunitz-Type Inhibitor from the Sea Anemone <em>Heteractis crispa</em>

by Emma Kozlovkaya, Jan Tytgat, Yaroslav Andreev, Steve Peigneur, Stanislav Anastyuk, Marina Isaeva, Victoria Chausova, Elena Zelepuga, Margarita Monastyrnaya, Elena Leychenko, Irina Gladkikh
Published 2012-07-01

Phoneutria nigriventer Spider Toxin PnTx2-1 (δ-Ctenitoxin-Pn1a) Is a Modulator of Sodium Channel Gating

by Steve Peigneur, Ana Luiza B. Paiva, Marta N. Cordeiro, Márcia H. Borges, Marcelo R. V. Diniz, Maria Elena de Lima, Jan Tytgat
Published 2018-08-01

Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel KV10.1.

by Lien Moreels, Chinmay Bhat, Manuela Voráčová, Steve Peigneur, Hannah Goovaerts, Eero Mäki-Lohiluoma, Farrah Zahed, Luis A Pardo, Jari Yli-Kauhaluoma, Paula Kiuru, Jan Tytgat
Published 2017-01-01

Kunitz-Type Peptides from the Sea Anemone <i>Heteractis crispa</i> Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities

by Irina Gladkikh, Steve Peigneur, Oksana Sintsova, Ernesto Lopes Pinheiro-Junior, Anna Klimovich, Alexander Menshov, Anatoly Kalinovsky, Marina Isaeva, Margarita Monastyrnaya, Emma Kozlovskaya, Jan Tytgat, Elena Leychenko
Published 2020-11-01

New Insectotoxin from Tibellus Oblongus Spider Venom Presents Novel Adaptation of ICK Fold

by Yuliya Korolkova, Ekaterina Maleeva, Alexander Mikov, Anna Lobas, Elizaveta Solovyeva, Mikhail Gorshkov, Yaroslav Andreev, Steve Peigneur, Jan Tytgat, Fedor Kornilov, Vladislav Lushpa, Konstantin Mineev, Sergey Kozlov
Published 2021-01-01

Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.

by Eline K. M. Lebbe, Maarten G. K. Ghequire, Steve Peigneur, Bea G. Mille, Prabha Devi, Samuthirapandian Ravichandran, Etienne Waelkens, Lisette D’Souza, René De Mot, Jan Tytgat
Published 2016-10-01

Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors

by Iziara F. Florentino, Daiany P.B. Silva, Carina Sofia Cardoso, Ricardo Menegatti, Flávio S. de Carvalho, Luciano M. Lião, Paulo M. Pinto, Steve Peigneur, Elson A. Costa, Jan Tytgat
Published 2019-07-01

New Insights into the Type II Toxins from the Sea Anemone <i>Heteractis crispa</i>

by Rimma S. Kalina, Steve Peigneur, Elena A. Zelepuga, Pavel S. Dmitrenok, Aleksandra N. Kvetkina, Natalia Y. Kim, Elena V. Leychenko, Jan Tytgat, Emma P. Kozlovskaya, Margarita M. Monastyrnaya, Irina N. Gladkikh
Published 2020-01-01

PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer

by Armando Alexei Rodríguez, Anoland Garateix, Emilio Salceda, Steve Peigneur, André Junqueira Zaharenko, Tirso Pons, Yúlica Santos, Roberto Arreguín, Ludger Ständker, Wolf-Georg Forssmann, Jan Tytgat, Rosario Vega, Enrique Soto
Published 2018-02-01

3D Pharmacophore-Based Discovery of Novel K_V10.1 Inhibitors with Antiproliferative Activity

by Žan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič
Published 2021-03-01

Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model

by Oksana Sintsova, Irina Gladkikh, Margarita Monastyrnaya, Valentin Tabakmakher, Ekaterina Yurchenko, Ekaterina Menchinskaya, Еvgeny Pislyagin, Yaroslav Andreev, Sergey Kozlov, Steve Peigneur, Jan Tytgat, Dmitry Aminin, Emma Kozlovskaya, Elena Leychenko
Published 2021-03-01

Chemical Synthesis, Proper Folding, Na_v Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1

by Sébastien Nicolas, Claude Zoukimian, Frank Bosmans, Jérôme Montnach, Sylvie Diochot, Eva Cuypers, Stephan De Waard, Rémy Béroud, Dietrich Mebs, David Craik, Didier Boturyn, Michel Lazdunski, Jan Tytgat, Michel De Waard
Published 2019-06-01

Biochemical and Electrophysiological Characterization of Two Sea Anemone Type 1 Potassium Toxins from a Geographically Distant Population of Bunodosoma caissarum

by André J. Zaharenko, Jan Tytgat, José C. Freitas, Adriano M. C. Pimenta, José E. P. W. Bicudo, Gabriela G. Montandon, Juliana S. Cassoli, Bruno Madio, Diego J. B. Orts, Steve Peigneur
Published 2013-03-01

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

by Caroline M. Cremonez, Mohitosh Maiti, Steve Peigneur, Juliana Silva Cassoli, Alexandre A. A. Dutra, Etienne Waelkens, Eveline Lescrinier, Piet Herdewijn, Maria Elena de Lima, Adriano M. C. Pimenta, Eliane C. Arantes, Jan Tytgat
Published 2016-09-01

The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels

by Ana C. N. Freitas, Steve Peigneur, Flávio H. P. Macedo, José E. Menezes-Filho, Paul Millns, Liciane F. Medeiros, Maria A. Arruda, Jader Cruz, Nicholas D. Holliday, Jan Tytgat, Gareth Hathway, Maria E. de Lima
Published 2018-01-01

Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report

by Aleksandra Nijak, Alain J. Labro, Hans De Wilde, Hans De Wilde, Wendy Dewals, Steve Peigneur, Jan Tytgat, Dirk Snyders, Ewa Sieliwonczyk, Eline Simons, Emeline Van Craenenbroeck, Dorien Schepers, Lut Van Laer, Johan Saenen, Bart Loeys, Bart Loeys, Maaike Alaerts
Published 2020-07-01

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

by Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets, Rudi Vennekens
Published 2017-03-01

Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3

by Andrei M. Gigolaev, Alexey I. Kuzmenkov, Steve Peigneur, Valentin M. Tabakmakher, Valentin M. Tabakmakher, Ernesto L. Pinheiro-Junior, Anton O. Chugunov, Anton O. Chugunov, Anton O. Chugunov, Roman G. Efremov, Roman G. Efremov, Roman G. Efremov, Jan Tytgat, Alexander A. Vassilevski, Alexander A. Vassilevski
Published 2020-07-01

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain

by Dmitrii Kulbatskii, Zakhar Shenkarev, Zakhar Shenkarev, Maxim Bychkov, Eugene Loktyushov, Mikhail Shulepko, Sergey Koshelev, Igor Povarov, Alexander Popov, Alexander Popov, Steve Peigneur, Anton Chugunov, Anton Chugunov, Anton Chugunov, Sergey Kozlov, Irina Sharonova, Roman Efremov, Roman Efremov, Roman Efremov, Vladimir Skrebitsky, Jan Tytgat, Mikhail Kirpichnikov, Mikhail Kirpichnikov, Ekaterina Lyukmanova, Ekaterina Lyukmanova, Ekaterina Lyukmanova
Published 2021-09-01

Pioneering Study on Rhopalurus crassicauda Scorpion Venom: Isolation and Characterization of the Major Toxin and Hyaluronidase

by Caio B. Abreu, Karla C. F. Bordon, Felipe A. Cerni, Isadora S. Oliveira, Carla Balenzuela, Gabriel M. Alexandre-Silva, Karina F. Zoccal, Mouzarllem B. Reis, Mouzarllem B. Reis, Gisele A. Wiezel, Steve Peigneur, Ernesto L. Pinheiro-Júnior, Jan Tytgat, Tiago M. Cunha, Loic Quinton, Lúcia H. Faccioli, Eliane C. Arantes, Umberto Zottich, Manuela B. Pucca
Published 2020-08-01