The Onchocerciasis Vaccine for Africa--TOVA--Initiative.

by Peter J Hotez, Maria Elena Bottazzi, Bin Zhan, Benjamin L Makepeace, Thomas R Klei, David Abraham, David W Taylor, Sara Lustigman
Published 2015-01-01

A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection.

by Meagan A Barry, Leroy Versteeg, Qian Wang, Jeroen Pollet, Bin Zhan, Fabian Gusovsky, Maria Elena Bottazzi, Peter J Hotez, Kathryn M Jones
Published 2019-05-01

A new patient registry for Chagas disease

by Peter Hotez, Maria Elena Bottazzi, Nathalie Strub-Wourgaft, Sergio Sosa-Estani, Faustino Torrico, Leire Pajín, Marcelo Abril, Javier Sancho, Igor C. Almeida
Published 2020-10-01

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection.

by Sridhar Arumugam, Junfei Wei, Zhuyun Liu, David Abraham, Aaron Bell, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan, Sara Lustigman, Thomas R Klei
Published 2016-04-01

<i>Schistosoma Haematobium</i> Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis

by Gebeyaw G. Mekonnen, Bemnet A. Tedla, Darren Pickering, Luke Becker, Lei Wang, Bin Zhan, Maria Elena Bottazzi, Alex Loukas, Javier Sotillo, Mark S. Pearson
Published 2020-07-01

Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs.

by Alex Loukas, Jeffrey M Bethony, Susana Mendez, Ricardo T Fujiwara, Gaddam Narsa Goud, Najju Ranjit, Bin Zhan, Karen Jones, Maria Elena Bottazzi, Peter J Hotez
Published 2005-10-01

Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection.

by Leroy Versteeg, Junfei Wei, Zhuyun Liu, Brian Keegan, Ricardo T Fujiwara, Kathryn M Jones, Oluwatoyin Asojo, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
Published 2020-02-01

An unfolding tragedy of Chagas disease in North America.

by Peter J Hotez, Eric Dumonteil, Miguel Betancourt Cravioto, Maria Elena Bottazzi, Roberto Tapia-Conyer, Sheba Meymandi, Unni Karunakara, Isabela Ribeiro, Rachel M Cohen, Bernard Pecoul
Published 2013-01-01

Texas and Mexico: sharing a legacy of poverty and neglected tropical diseases.

by Peter J Hotez, Maria Elena Bottazzi, Eric Dumonteil, Jesus G Valenzuela, Shaden Kamhawi, Jaime Ortega, Samuel Ponce de Leon Rosales, Miguel Betancourt Cravioto, Roberto Tapia-Conyer
Published 2012-01-01

Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans.

by Parakkal Jovvian George, Jessica A Hess, Sonia Jain, John B Patton, Tingting Zhan, Nancy Tricoche, Bin Zhan, Maria Elena Bottazzi, Peter J Hotez, David Abraham, Sara Lustigman
Published 2019-09-01

Chagas disease: "the new HIV/AIDS of the Americas".

by Peter J Hotez, Eric Dumonteil, Laila Woc-Colburn, Jose A Serpa, Sarah Bezek, Morven S Edwards, Camden J Hallmark, Laura W Musselwhite, Benjamin J Flink, Maria Elena Bottazzi
Published 2012-01-01

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice.

by Jessica A Hess, Bin Zhan, April R Torigian, John B Patton, Nikolai Petrovsky, Tingting Zhan, Maria Elena Bottazzi, Peter J Hotez, Thomas R Klei, Sara Lustigman, David Abraham
Published 2016-07-01

Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.

by Bin Zhan, Sridhar Arumugam, Malcolm W Kennedy, Nancy Tricoche, Lu-Yun Lian, Oluwatoyin A Asojo, Sasisekhar Bennuru, Maria Elena Bottazzi, Peter J Hotez, Sara Lustigman, Thomas R Klei
Published 2018-10-01

The BENEFIT Trial: Where Do We Go from Here?

by Bernard Pecoul, Carolina Batista, Eric Stobbaerts, Isabella Ribeiro, Rafael Vilasanjuan, Joaquim Gascon, Maria Jesus Pinazo, Silvia Moriana, Silvia Gold, Ana Pereiro, Miriam Navarro, Faustino Torrico, Maria Elena Bottazzi, Peter J Hotez
Published 2016-02-01

Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response.

by Junfei Wei, Leroy Versteeg, Zhuyun Liu, Brian Keegan, Ana Clara Gazzinelli-Guimarães, Ricardo T Fujiwara, Neima Briggs, Kathryn M Jones, Ulrich Strych, Coreen M Beaumier, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
Published 2017-07-01

Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection

by Julio V. Cruz-Chan, Liliana E. Villanueva-Lizama, Leroy Versteeg, Ashish Damania, Maria José Villar, Cristina González-López, Brian Keegan, Jeroen Pollet, Fabian Gusovsky, Peter J. Hotez, Maria Elena Bottazzi, Kathryn M. Jones
Published 2021-02-01

Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice

by Nathan M. Ryan, Jessica A. Hess, Fernando Pardo-Manuel de Villena, Benjamin E. Leiby, Ayako Shimada, Lei Yu, Amir Yarmahmoodi, Nikolai Petrovsky, Bin Zhan, Maria Elena Bottazzi, Benjamin L. Makepeace, Sara Lustigman, David Abraham
Published 2021-01-01

Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm.

by Neima Briggs, Junfei Wei, Leroy Versteeg, Bin Zhan, Brian Keegan, Ashish Damania, Jeroen Pollet, Kelly S Hayes, Coreen Beaumier, Christopher A Seid, Jamie Leong, Richard K Grencis, Maria Elena Bottazzi, K Jagannadha Sastry, Peter J Hotez
Published 2018-08-01

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development.

by Tiffany Bouchery, Kara Filbey, Amy Shepherd, Jodie Chandler, Deepa Patel, Alfonso Schmidt, Mali Camberis, Adeline Peignier, Adam A T Smith, Karen Johnston, Gavin Painter, Mark Pearson, Paul Giacomin, Alex Loukas, Maria-Elena Bottazzi, Peter Hotez, Graham LeGros
Published 2018-03-01

Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine.

by Jill B Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J Hotez, David Diemert, Jeffrey M Bethony
Published 2017-02-01