Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver

by Egner, Patricia A., Groopman, John D., Satayavivad, Jutamaad, Sriwattanapong, Kanokwan, Slocum, Stephen L., Chawanthayatham, Supawadee, Fedeles, Bogdan I, Croy, Robert G, Essigmann, John M
Published 2018

Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation

by Cui, Liang, Ye, Wenjie, Wishnok, John S., Taghizadeh, Koli, Dedon, Peter C., Prestwich, Erin, Tannenbaum, Steven Robert
Published 2013

PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

by Allocca, Mariacarmela, Corrigan, Joshua, Fake, Kimberly, Samson, Leona D, Calvo, Jennifer A.
Published 2018

Direct Observation of Multiple Tautomers of Oxythiamine and their Recognition by the Thiamine Pyrophosphate Riboswitch

by Singh, Vipender, Peng, Chunte Sam, Li, Deyu, Mitra, Koyel, Silvestre, Katherine J., Tokmakoff, Andrei, Essigmann, John M.
Published 2015

Diarrhea as a cause of mortality in a mouse model of infectious colitis

by Borenshtein, Diana, Fry, Rebecca C., Groff, Elizabeth B., Nambiar, Prashant R., Carey, Vincent J., Fox, James G., Schauer, David B.
Published 2010

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

by Fedeles, Bogdan I., Freudenthal, Bret D., Yau, Emily, Singh, Vipender, Chang, Shiou-chi, Li, Deyu, Delaney, James C., Wilson, Samuel H., Essigmann, John M.
Published 2016

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

by Chan, Tsz Yan Clement, Pang, Yan Ling Joy, Deng, Wenjun, Indrakanti, Ramesh Babu, Dyavaiah, Madhu, Begley, Thomas J., Dedon, Peter C.
Published 2013

Increased Levels of Inosine in a Mouse Model of Inflammation

by Prestwich, Erin, Mangerich, Aswin, Pang, Bo, McFaline, Jose Luis, Lonkar, Pallavi, Sullivan, Matthew R., Trudel, Laura J., Taghizedeh, Koli, Dedon, Peter C.
Published 2014

In Situ Analysis of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Oxidation Reveals Sequence- and Agent-Specific Damage Spectra

by Lim, Kok Seong, Cui, Liang, Taghizadeh, Koli, Wishnok, John S., Chan, Wan Simon, DeMott, Michael S., Babu, I. Ramesh, Dedon, Peter C., Tannenbaum, Steven Robert
Published 2014

Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

by Margulies, Carrie Marie, Chaim, Isaac Alexander, Mazumder, Aprotim, Criscione, June, Samson, Leona D
Published 2018

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids i...

by Svensson, J. Peter, Quirós Pesudo, Laia, McRee, Siobhan K., Adeleye, Yeyejide A., Carmichael, Paul, Quiros Pesudo, Laia, Samson, Leona D
Published 2013

Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity

by Peng, Chunte, Fedeles, Bogdan I., Singh, Vipender, Li, Deyu, Amariuta, Tiffany, Essigmann, John M., Tokmakoff, Andrei
Published 2015

O[superscript 6]-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

by Noonan, Ericka M., Shah, Dharini, Yaffe, Michael B, Lauffenburger, Douglas A, Samson, Leona D
Published 2014

Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels

by Mehta, Geeta, Williams, Courtney M., Alvarez, Luis, Lesniewski, Martha, Griffith, Linda G., Kamm, Roger Dale
Published 2015

Removal of N-Alkyl Modifications from N[superscript 2]-Alkylguanine and N[superscript 4]-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

by Li, Deyu, Fedeles, Bogdan I., Shrivastav, Nidhi, Delaney, James C., Yang, Xuedong, Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Published 2013

A system for exposing molecules and cells to biologically relevant and accurately controlled steady-state concentrations of nitric oxide and oxygen

by Dendroulakis, Vasileios, Russell, Brandon S., Trudel, Laura J., Wogan, Gerald N., Deen, William M., Dedon, Peter C., Elmquist, C. Eric
Published 2015

Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance

by Svensson, J. Peter, Quiros Pesudo, Laia, Fry, Rebecca C., Adeleye, Yeyejide A., Carmichael, Paul, Samson, Leona D
Published 2011

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

by Chionh, Yok Hian, McBee, Megan, Babu, I. Ramesh, Hia, Fabian, Lin, Wenwei, Zhao, Wei, Cao, Jianshu, Dziergowska, Agnieszka, Malkiewicz, Andrzej, Begley, Thomas J., Alonso, Sylvie, Dedon, Peter C.
Published 2016

Chemistry meets biology in colitis-associated carcinogenesis

by Mangerich, Aswin, Dedon, Peter C., Fox, James G., Tannenbaum, Steven Robert, Wogan, Gerald N.
Published 2014

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

by Tentner, Andrea R., Lee, Michael J., Ostheimer, Gerard, Samson, Leona D., Lauffenburger, Douglas A., Yaffe, Michael B.
Published 2012