TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

by Arjan van Caam, Wojciech Madej, Amaya Garcia de Vinuesa, Marie-José Goumans, Peter ten Dijke, Esmeralda Blaney Davidson, Peter van der Kraan
Published 2017-05-01

A Signaling Crosstalk between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival

by Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Rebeca Méndez, Laura Almalé, María García-Álvaro, Peter ten Dijke, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez
Published 2020-03-01

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva

by Jie Cai, Valeria V. Orlova, Xiujuan Cai, Elisabeth M.W. Eekhoff, Keqin Zhang, Duanqing Pei, Guangjin Pan, Christine L. Mummery, Peter ten Dijke
Published 2015-12-01

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

by Jiang Ren, Marcel Smid, Josephine Iaria, Daniela C. F. Salvatori, Hans van Dam, Hong Jian Zhu, John W. M. Martens, Peter ten Dijke
Published 2019-09-01

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients

by Ulrike Neckmann, Camilla Wolowczyk, Martina Hall, Eivind Almaas, Jiang Ren, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim, Geir Bjørkøy, Peter ten Dijke, Toril Holien
Published 2019-11-01

MnTBAP Reverses Pulmonary Vascular Remodeling and Improves Cardiac Function in Experimentally Induced Pulmonary Arterial Hypertension

by Maria Catalina Gomez-Puerto, Xiao-Qing Sun, Ingrid Schalij, Mar Orriols, Xiaoke Pan, Robert Szulcek, Marie-José Goumans, Harm-Jan Bogaard, Qian Zhou, Peter ten Dijke
Published 2020-06-01

Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior

by Tao Zhang, Irma van Die, Boris Tefsen, Boris Tefsen, Sandra J. van Vliet, Lisa C. Laan, Jing Zhang, Peter ten Dijke, Manfred Wuhrer, Ana I. Belo
Published 2020-06-01

Antisense-oligonucleotide mediated exon skipping in activin-receptor-like kinase 2: inhibiting the receptor that is overactive in fibrodysplasia ossificans progressiva.

by Songting Shi, Jie Cai, David J J de Gorter, Gonzalo Sanchez-Duffhues, Dwi U Kemaladewi, Willem M H Hoogaars, Annemieke Aartsma-Rus, Peter A C 't Hoen, Peter ten Dijke
Published 2013-01-01

Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor

by Dwi U Kemaladewi, Svitlana Pasteuning, Joke W van der Meulen, Sandra H van Heiningen, Gert-Jan van Ommen, Peter ten Dijke, Annemieke Aartsma-Rus, Peter AC 't Hoen, Willem M Hoogaars
Published 2014-01-01

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

by Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma- van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam
Published 2019-11-01

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.

by Maarten van Dinther, Juan Zhang, Stella E Weidauer, Verena Boschert, Eva-Maria Muth, Achim Knappik, David J J de Gorter, Puck B van Kasteren, Christian Frisch, Thomas D Mueller, Peter ten Dijke
Published 2013-01-01

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice

by María González-Núñez, Adela S. Riolobos, Orlando Castellano, Isabel Fuentes-Calvo, María de los Ángeles Sevilla, Bárbara Oujo, Miguel Pericacho, Ignacio Cruz-Gonzalez, Fernando Pérez-Barriocanal, Peter ten Dijke, Jose M. López-Novoa
Published 2015-11-01

Cripto favours chondrocyte hypertrophy via TGF-beta SMAD1/5 signaling in experimental osteoarthritis

by Gonzalo Sanchez-Duffhues, Amaya Garcia de Vinuesa Antuñano, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter ten Dijke
Published 2021-04-01

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

by Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin, Fangfang Zhou, Long Zhang
Published 2017-04-01

BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model

by SongTing Shi, Willem M.H. Hoogaars, David J.J. de Gorter, Sandra H. van Heiningen, Herbert Y. Lin, Charles C. Hong, Dwi U. Kemaladewi, Annemieke Aartsma-Rus, Peter ten Dijke, Peter A.C. 't Hoen
Published 2011-02-01

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation

by Xueyu Chen, Mar Orriols, Frans J. Walther, Frans J. Walther, El Houari Laghmani, Annemarie M. Hoogeboom, Anne C. B. Hogen-Esch, Pieter S. Hiemstra, Gert Folkerts, Marie-José T. H. Goumans, Peter ten Dijke, Nicholas W. Morrell, Gerry T. M. Wagenaar
Published 2017-07-01

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

by Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou, Long Zhang
Published 2017-12-01

Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides

by Sofia Karkampouna, Boudewijn PT Kruithof, Peter Kloen, Miryam C Obdeijn, Annelies MA van der Laan, Hans J Tanke, Dwi U Kemaladewi, Willem MH Hoogaars, Peter AC 't Hoen, Annemieke Aartsma-Rus, Ian M Clark, Peter ten Dijke, Marie-José Goumans, Marianna Kruithof-de Julio
Published 2014-01-01

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

by Gonzalo Sánchez‐Duffhues, Eleanor Williams, Pascal Benderitter, Valeria Orlova, Michiel vanWijhe, Amaya Garcia de Vinuesa, Georgina Kerr, Josselin Caradec, Kirsten Lodder, Hetty C. deBoer, Marie‐José Goumans, Elisabeth M W Eekhoff, Antonio Morales‐Piga, Javier Bachiller‐Corral, Pieter Koolwijk, Alex N. Bullock, Jan Hoflack, Peter tenDijke
Published 2019-11-01

Author Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

by Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Published 2019-11-01