Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone.

by Giorgio Giacomo Galli, Kristian Honnens de Lichtenberg, Matteo Carrara, Wolfgang Hans, Manuela Wuelling, Bettina Mentz, Hinke Arnolda Multhaupt, Cathrine Kolster Fog, Klaus Thorleif Jensen, Juri Rappsilber, Andrea Vortkamp, Les Coulton, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Raffaele Adolfo Calogero, John Robert Couchman, Anders Henrik Lund
Published 2012-01-01

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.

by Isabel Rubio-Aliaga, Gerhard K H Przemeck, Helmut Fuchs, Valérie Gailus-Durner, Thure Adler, Wolfgang Hans, Marion Horsch, Birgit Rathkolb, Jan Rozman, Anja Schrewe, Sibylle Wagner, Sabine M Hoelter, Lore Becker, Thomas Klopstock, Wolfgang Wurst, Eckhard Wolf, Martin Klingenspor, Boris T Ivandic, Dirk H Busch, Johannes Beckers, Martin Hrabé de Angelis
Published 2009-01-01

Meis1: effects on motor phenotypes and the sensorimotor system in mice

by Aaro V. Salminen, Lillian Garrett, Barbara Schormair, Jan Rozman, Florian Giesert, Kristina M. Niedermeier, Lore Becker, Birgit Rathkolb, Ildikó Rácz, German Mouse Clinic Consortium, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Andreas Zimmer, Valérie Gailus-Durner, Miguel Torres, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Sabine M. Hölter, Juliane Winkelmann
Published 2017-08-01

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

by Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth, Frauke Neff, Jan Rozman, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Eckhard Wolf, Bernhard Aigner
Published 2017-08-01

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

by Marten Szibor, Praveen K. Dhandapani, Eric Dufour, Kira M. Holmström, Yuan Zhuang, Isabelle Salwig, Ilka Wittig, Juliana Heidler, Zemfira Gizatullina, Timur Gainutdinov, German Mouse Clinic Consortium, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Jatin Nandania, Vidya Velagapudi, Astrid Wietelmann, Pierre Rustin, Frank N. Gellerich, Howard T. Jacobs, Thomas Braun
Published 2017-02-01

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.

by Arianna Tocchetti, Charlotte Blanche Ekalle Soppo, Fabio Zani, Fabrizio Bianchi, Maria Cristina Gagliani, Benedetta Pozzi, Jan Rozman, Ralf Elvert, Nicole Ehrhardt, Birgit Rathkolb, Corinna Moerth, Marion Horsch, Helmut Fuchs, Valérie Gailus-Durner, Johannes Beckers, Martin Klingenspor, Eckhard Wolf, Martin Hrabé de Angelis, Eugenio Scanziani, Carlo Tacchetti, Giorgio Scita, Pier Paolo Di Fiore, Nina Offenhäuser
Published 2010-01-01

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.

by Pawel K Olszewski, Jan Rozman, Josefin A Jacobsson, Birgit Rathkolb, Siv Strömberg, Wolfgang Hans, Anica Klockars, Johan Alsiö, Ulf Risérus, Lore Becker, Sabine M Hölter, Ralf Elvert, Nicole Ehrhardt, Valérie Gailus-Durner, Helmut Fuchs, Robert Fredriksson, Eckhard Wolf, Thomas Klopstock, Wolfgang Wurst, Allen S Levine, Claude Marcus, Martin Hrabě de Angelis, Martin Klingenspor, Helgi B Schiöth, Manfred W Kilimann
Published 2012-01-01

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.

by Christophe Côme, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimentel, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H Busch, Markus W Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck
Published 2016-01-01

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.

by Sudhir Kumar, Birgit Rathkolb, Elisabeth Kemter, Sibylle Sabrautzki, Dian Michel, Thure Adler, Lore Becker, Johannes Beckers, Dirk H Busch, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Ildikó Rácz, Jan Rozman, Ingrid Liliana Vargas Panesso, Alexandra Vernaleken, Andreas Zimmer, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Eckhard Wolf, Bernhard Aigner
Published 2016-01-01

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

by Lore Becker, Eva Kling, Evelyn Schiller, Ramona Zeh, Anja Schrewe, Sabine M Hölter, Ilona Mossbrugger, Julia Calzada-Wack, Valentina Strecker, Ilka Wittig, Iulia Dumitru, Tina Wenz, Andreas Bender, Michaela Aichler, Dirk Janik, Frauke Neff, Axel Walch, Leticia Quintanilla-Fend, Thomas Floss, Raffi Bekeredjian, Valérie Gailus-Durner, Helmut Fuchs, Wolfgang Wurst, Thomas Meitinger, Holger Prokisch, Martin Hrabě de Angelis, Thomas Klopstock
Published 2014-01-01

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.

by Christoph Kleinschnitz, Henrike Grund, Kirstin Wingler, Melanie E Armitage, Emma Jones, Manish Mittal, David Barit, Tobias Schwarz, Christian Geis, Peter Kraft, Konstanze Barthel, Michael K Schuhmann, Alexander M Herrmann, Sven G Meuth, Guido Stoll, Sabine Meurer, Anja Schrewe, Lore Becker, Valérie Gailus-Durner, Helmut Fuchs, Thomas Klopstock, Martin Hrabé de Angelis, Karin Jandeleit-Dahm, Ajay M Shah, Norbert Weissmann, Harald H H W Schmidt
Published 2010-09-01

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

by Viola André, Christine Gau, Angelika Scheideler, Juan A Aguilar-Pimentel, Oana V Amarie, Lore Becker, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Dirk Janik, Kristin Moreth, Frauke Neff, Manuela Östereicher, Ildiko Racz, Birgit Rathkolb, Jan Rozman, Raffi Bekeredjian, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Markus Brielmeier, Helmut Fuchs, Martin Hrabé de Angelis
Published 2018-04-01

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.

by Sabine M Hölter, Mary Stromberg, Marina Kovalenko, Lillian Garrett, Lisa Glasl, Edith Lopez, Jolene Guide, Alexander Götz, Wolfgang Hans, Lore Becker, Birgit Rathkolb, Jan Rozman, Anja Schrewed, Martin Klingenspor, Thomas Klopstock, Holger Schulz, Eckhard Wolf, Wolfgang Wursta, Tammy Gillis, Hiroko Wakimoto, Jonathan Seidman, Marcy E MacDonald, Susan Cotman, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Jong-Min Lee, Vanessa C Wheeler
Published 2013-01-01

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

by Henning Jacobsen, Kerstin Walendy-Gnirß, Nilgün Tekin-Bubenheim, Nancy Mounogou Kouassi, Isabel Ben-Batalla, Nikolaus Berenbrok, Martin Wolff, Vinicius Pinho dos Reis, Martin Zickler, Lucas Scholl, Annette Gries, Hanna Jania, Andreas Kloetgen, Arne Düsedau, Gundula Pilnitz-Stolze, Aicha Jeridi, Ali Önder Yildirim, Helmut Fuchs, Valerie Gailus-Durner, Claudia Stoeger, Martin Hrabe de Angelis, Tatjana Manuylova, Karin Klingel, Fiona J. Culley, Jochen Behrends, Sonja Loges, Bianca Schneider, Susanne Krauss-Etschmann, Peter Openshaw, Gülsah Gabriel
Published 2021-08-01

Pleiotropic functions for transcription factor zscan10.

by Petra Kraus, Sivakamasundari V, Hong Bing Yu, Xing Xing, Siew Lan Lim, Thure Adler, Juan Antonio Aguilar Pimentel, Lore Becker, Alexander Bohla, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Eva Janas, Kristin Moreth, Cornelia Prehn, Oliver Puk, Birgit Rathkolb, Jan Rozman, Jerzy Adamski, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Frauke Neff, Markus Ollert, Tobias Stoeger, Ali Önder Yildrim, Oliver Eickelberg, Eckhard Wolf, Wolfgang Wurst, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Thomas Lufkin, Lawrence W Stanton
Published 2014-01-01

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

by Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S. Henzel, Sabine M. Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L. Pearson, Ildiko Racz, Birgit Rathkolb, Devon P. Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Dan Ehninger
Published 2017-07-01

High-throughput discovery of genetic determinants of circadian misalignment.

by Tao Zhang, Pancheng Xie, Yingying Dong, Zhiwei Liu, Fei Zhou, Dejing Pan, Zhengyun Huang, Qiaocheng Zhai, Yue Gu, Qingyu Wu, Nobuhiko Tanaka, Yuichi Obata, Allan Bradley, Christopher J Lelliott, Sanger Institute Mouse Genetics Project, Lauryl M J Nutter, Colin McKerlie, Ann M Flenniken, Marie-France Champy, Tania Sorg, Yann Herault, Martin Hrabe De Angelis, Valerie Gailus Durner, Ann-Marie Mallon, Steve D M Brown, Terry Meehan, Helen E Parkinson, Damian Smedley, K C Kent Lloyd, Jun Yan, Xiang Gao, Je Kyung Seong, Chi-Kuang Leo Wang, Radislav Sedlacek, Yi Liu, Jan Rozman, Ling Yang, Ying Xu
Published 2020-01-01

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.

by John F Staropoli, Larissa Haliw, Sunita Biswas, Lillian Garrett, Sabine M Hölter, Lore Becker, Sergej Skosyrski, Patricia Da Silva-Buttkus, Julia Calzada-Wack, Frauke Neff, Birgit Rathkolb, Jan Rozman, Anja Schrewe, Thure Adler, Oliver Puk, Minxuan Sun, Jack Favor, Ildikó Racz, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Edith Lopez, Hayat Harati, Eric Hill, Daniela S Krause, Jolene Guide, Ella Dragileva, Evan Gale, Vanessa C Wheeler, Rose-Mary Boustany, Diane E Brown, Sylvie Breton, Klaus Ruether, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Susan L Cotman
Published 2012-01-01

Introduction to the EQIPD quality system

by Anton Bespalov, René Bernard, Anja Gilis, Björn Gerlach, Javier Guillén, Vincent Castagné, Isabel A Lefevre, Fiona Ducrey, Lee Monk, Sandrine Bongiovanni, Bruce Altevogt, María Arroyo-Araujo, Lior Bikovski, Natasja de Bruin, Esmeralda Castaños-Vélez, Alexander Dityatev, Christoph H Emmerich, Raafat Fares, Chantelle Ferland-Beckham, Christelle Froger-Colléaux, Valerie Gailus-Durner, Sabine M Hölter, Martine CJ Hofmann, Patricia Kabitzke, Martien JH Kas, Claudia Kurreck, Paul Moser, Malgorzata Pietraszek, Piotr Popik, Heidrun Potschka, Ernesto Prado Montes de Oca, Leonardo Restivo, Gernot Riedel, Merel Ritskes-Hoitinga, Janko Samardzic, Michael Schunn, Claudia Stöger, Vootele Voikar, Jan Vollert, Kimberley E Wever, Kathleen Wuyts, Malcolm R MacLeod, Ulrich Dirnagl, Thomas Steckler
Published 2021-05-01

Human and mouse essentiality screens as a resource for disease gene discovery

by Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A. Murray, Mary E. Dickinson, Maja Bucan, Lauryl M. J. Nutter, Kevin A. Peterson, Hamed Haselimashhadi, Ann M. Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G. Lanza, Arthur L. Beaudet, Jason D. Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J. Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J. Adams, John R. Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E. Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, K. C.  Kent Lloyd, Steve D. M. Brown, Helen Parkinson, Terrence F. Meehan, Damian Smedley, The Genomics England Research Consortium, The International Mouse Phenotyping Consortium
Published 2020-01-01