Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium

by Steve D. M. Brown, Mark W. Moore
Published 2012-05-01

Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.

by Steve D M Brown, John M Hancock, Hilary Gates
Published 2006-08-01

The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

by Oana Kubinyecz, Pratik P. Vikhe, Thomas Purnell, Steve D. M. Brown, Hilda Tateossian
Published 2020-05-01

Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media

by Pratik P. Vikhe, Hilda Tateossian, Gurpreet Bharj, Steve D.M. Brown, Derek W. Hood
Published 2020-02-01

Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung

by Hilda Tateossian, Susan Morse, Michelle M. Simon, Charlotte H. Dean, Steve D. M. Brown
Published 2015-12-01

Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia.

by Philomena Mburu, María Rosario Romero, Helen Hilton, Andrew Parker, Stuart Townsend, Yoshiaki Kikkawa, Steve D M Brown
Published 2010-07-01

The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.

by Jennifer Olt, Philomena Mburu, Stuart L Johnson, Andy Parker, Stephanie Kuhn, Mike Bowl, Walter Marcotti, Steve D M Brown
Published 2014-01-01

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

by Apoorva Mulay, Derek W. Hood, Debbie Williams, Catherine Russell, Steve D. M. Brown, Lynne Bingle, Michael Cheeseman, Colin D. Bingle
Published 2018-02-01

Regulatory variation at glypican-3 underlies a major growth QTL in mice.

by Fiona Oliver, Julian K Christians, Xiaojun Liu, Susan Rhind, Vinesh Verma, Claire Davison, Steve D M Brown, Paul Denny, Peter D Keightley
Published 2005-05-01

The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells

by Andrew Parker, Sally H. Cross, Ian J. Jackson, Rachel Hardisty-Hughes, Susan Morse, George Nicholson, Emma Coghill, Michael R. Bowl, Steve D. M. Brown
Published 2015-12-01

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse

by Derek Hood, Richard Moxon, Tom Purnell, Caroline Richter, Debbie Williams, Ali Azar, Michael Crompton, Sara Wells, Martin Fray, Steve D. M. Brown, Michael T. Cheeseman
Published 2016-01-01

Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.

by Silvia Corrochano, Maurizio Renna, Georgina Osborne, Sarah Carter, Michelle Stewart, Joel May, Gillian P Bates, Steve D M Brown, David C Rubinsztein, Abraham Acevedo-Arozena
Published 2014-01-01

A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease

by Siddharth Sethi, Ilya E. Vorontsov, Ivan V. Kulakovskiy, Simon Greenaway, John Williams, Vsevolod J. Makeev, Steve D. M. Brown, Michelle M. Simon, Ann-Marie Mallon
Published 2020-11-01

An in vitro model of murine middle ear epithelium

by Apoorva Mulay, Khondoker M. Akram, Debbie Williams, Hannah Armes, Catherine Russell, Derek Hood, Stuart Armstrong, James P. Stewart, Steve D. M. Brown, Lynne Bingle, Colin D. Bingle
Published 2016-11-01

Transcript Analysis Reveals a Hypoxic Inflammatory Environment in Human Chronic Otitis Media With Effusion

by Mahmood F. Bhutta, Jane Lambie, Lindsey Hobson, Debbie Williams, Hayley E. Tyrer, George Nicholson, Steve D.M. Brown, Helen Brown, Chiara Piccinelli, Guillaume Devailly, James Ramsden, Michael T. Cheeseman
Published 2020-02-01

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.

by Christopher T Esapa, Fadil M Hannan, Valerie N Babinsky, Paul Potter, Gethin P Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker
Published 2015-01-01

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Sig...

by Christopher T Esapa, Sian E Piret, M Andrew Nesbit, Nellie Y Loh, Gethin Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker
Published 2016-01-01

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.

by Sian E Piret, Christopher T Esapa, Caroline M Gorvin, Rosie Head, Nellie Y Loh, Olivier Devuyst, Gethin Thomas, Steve D M Brown, Matthew Brown, Peter Croucher, Roger Cox, Rajesh V Thakker
Published 2012-01-01

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

by Arnaud P. J. Giese, Yi-Quan Tang, Ghanshyam P. Sinha, Michael R. Bowl, Adam C. Goldring, Andrew Parker, Mary J. Freeman, Steve D. M. Brown, Saima Riazuddin, Robert Fettiplace, William R. Schafer, Gregory I. Frolenkov, Zubair M. Ahmed
Published 2017-06-01

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.

by Michael T Cheeseman, Hayley E Tyrer, Debbie Williams, Tertius A Hough, Paras Pathak, Maria R Romero, Helen Hilton, Sulzhan Bali, Andrew Parker, Lucie Vizor, Tom Purnell, Kate Vowell, Sara Wells, Mahmood F Bhutta, Paul K Potter, Steve D M Brown
Published 2011-10-01