Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

by Roger D. Cox, Christopher D. Church
Published 2011-03-01

Commentary FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

by Samantha eLaber, Samantha eLaber, Roger D Cox
Published 2015-10-01

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.

by James S McTaggart, Sheena Lee, Michaela Iberl, Chris Church, Roger D Cox, Frances M Ashcroft
Published 2011-01-01

A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress

by Sian E. Piret, Eric Olinger, Anita A. C. Reed, M. Andrew Nesbit, Tertius A. Hough, Liz Bentley, Olivier Devuyst, Roger D. Cox, Rajesh V. Thakker
Published 2017-06-01

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model

by Fadil M Hannan, Caroline M Gorvin, Valerie N Babinsky, Mie K Olesen, Michelle Stewart, Sara Wells, Roger D Cox, Edward F Nemeth, Rajesh V Thakker
Published 2020-10-01

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

by Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Published 2021-01-01

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.

by Christopher T Esapa, Fadil M Hannan, Valerie N Babinsky, Paul Potter, Gethin P Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker
Published 2015-01-01

Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Sig...

by Christopher T Esapa, Sian E Piret, M Andrew Nesbit, Nellie Y Loh, Gethin Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker
Published 2016-01-01

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

by Alison J. Hugill, Michelle E. Stewart, Marianne A. Yon, Fay Probert, I. Jane Cox, Tertius A. Hough, Cheryl L. Scudamore, Liz Bentley, Gary Wall, Sara E. Wells, Roger D. Cox
Published 2015-11-01

Gene Dosage Effects at the Imprinted Gnas Cluster.

by Simon T Ball, Michelle L Kelly, Joan E Robson, Martin D Turner, Jackie Harrison, Lynn Jones, Diane Napper, Colin V Beechey, Tertius Hough, Antonius Plagge, Bruce M Cattanach, Roger D Cox, Jo Peters
Published 2013-01-01

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

by Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Published 2013-01-01

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

by Chris Church, Sheena Lee, Eleanor A L Bagg, James S McTaggart, Robert Deacon, Thomas Gerken, Angela Lee, Lee Moir, Jasmin Mecinović, Mohamed M Quwailid, Christopher J Schofield, Frances M Ashcroft, Roger D Cox
Published 2009-08-01

Pharmacological inhibition of FTO.

by Fiona McMurray, Marina Demetriades, WeiShen Aik, Myrte Merkestein, Holger Kramer, Daniel S Andrew, Cheryl L Scudamore, Tertius A Hough, Sara Wells, Frances M Ashcroft, Michael A McDonough, Christopher J Schofield, Roger D Cox
Published 2015-01-01

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

by Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Published 2013-01-01

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.

by Christopher T Esapa, Rosie A Head, Jeshmi Jeyabalan, Holly Evans, Tertius A Hough, Michael T Cheeseman, Eugene G McNally, Andrew J Carr, Gethin P Thomas, Matthew A Brown, Peter I Croucher, Steve D M Brown, Roger D Cox, Rajesh V Thakker
Published 2012-01-01

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.

by Angela W S Lee, Heidi Hengstler, Kathrin Schwald, Mauricio Berriel-Diaz, Desirée Loreth, Matthias Kirsch, Oliver Kretz, Carola A Haas, Martin Hrabě de Angelis, Stephan Herzig, Thomas Brümmendorf, Martin Klingenspor, Fritz G Rathjen, Jan Rozman, George Nicholson, Roger D Cox, Michael K E Schäfer
Published 2012-01-01

A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways

by Thomas Agnew, Michelle Goldsworthy, Carlos Aguilar, Anna Morgan, Michelle Simon, Helen Hilton, Chris Esapa, Yixing Wu, Heather Cater, Liz Bentley, Cheryl Scudamore, Joanna Poulton, Karl J. Morten, Kyle Thompson, Langping He, Steve D.M. Brown, Robert W. Taylor, Michael R. Bowl, Roger D. Cox
Published 2018-12-01

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

by Ali J. Chakera, Paul S. Hurst, Gill Spyer, Emmanuel O. Ogunnowo-Bada, William J. Marsh, Christine H. Riches, Chen-Yu Yueh, S. Pauliina Markkula, Jeffrey W. Dalley, Roger D. Cox, Ian A. Macdonald, Stephanie A. Amiel, Kenneth M. MacLeod, Lora K. Heisler, Andrew T. Hattersley, Mark L. Evans
Published 2018-11-01

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

by Lee Moir, Elena G. Bochukova, Rebecca Dumbell, Gareth Banks, Rasneer S. Bains, Patrick M. Nolan, Cheryl Scudamore, Michelle Simon, Kimberly A. Watson, Julia Keogh, Elana Henning, Audrey Hendricks, Stephen O'Rahilly, Inês Barroso, Adrienne E. Sullivan, David C. Bersten, Murray L. Whitelaw, Susan Kirsch, Elizabeth Bentley, I. Sadaf Farooqi, Roger D. Cox
Published 2017-11-01

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.

by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker
Published 2013-01-01