AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

by Laia Vil, Carles Roca, Ivet Elias, Alba Casellas, Ricardo Lage, Sylvie Franckhauser, Fatima Bosch
Published 2016-01-01

Long-term retinal PEDF overexpression prevents neovascularization in a murine adult model of retinopathy.

by Virginia Haurigot, Pilar Villacampa, Albert Ribera, Assumpcio Bosch, David Ramos, Jesus Ruberte, Fatima Bosch
Published 2012-01-01

Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells.

by Joan Teichenne, Meritxell Morró, Alba Casellas, Veronica Jimenez, Noelia Tellez, Adrien Leger, Fatima Bosch, Eduard Ayuso
Published 2015-01-01

AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease

by Laia Vilà, Ivet Elias, Carles Roca, Albert Ribera, Tura Ferré, Alba Casellas, Ricardo Lage, Sylvie Franckhauser, Fatima Bosch
Published 2014-01-01

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

by Yi-Chun Loraine Tung, Eduard Ayuso, Xiaoye Shan, Fatima Bosch, Stephen O'Rahilly, Anthony P Coll, Giles S H Yeo
Published 2010-01-01

AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer.

by Miguel A Muñoz-Lorente, Paula Martínez, Águeda Tejera, Kurt Whittemore, Ana Carolina Moisés-Silva, Fàtima Bosch, Maria A Blasco
Published 2018-08-01

Phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis.

by Miguel García, Anna Pujol, Albert Ruzo, Efrén Riu, Jesús Ruberte, Anna Arbós, Anna Serafín, Beatriz Albella, Juan Emilio Felíu, Fátima Bosch
Published 2009-08-01

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

by Juan Manuel Povedano, Paula Martinez, Rosa Serrano, Águeda Tejera, Gonzalo Gómez-López, Maria Bobadilla, Juana Maria Flores, Fátima Bosch, Maria A Blasco
Published 2018-01-01

AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice

by Cristina Mallol, Estefania Casana, Veronica Jimenez, Alba Casellas, Virginia Haurigot, Claudia Jambrina, Victor Sacristan, Meritxell Morró, Judith Agudo, Laia Vilà, Fatima Bosch
Published 2017-07-01

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

by Jenny M. Hoffmann, John R. Grünberg, Christopher Church, Ivet Elias, Vilborg Palsdottir, John-Olov Jansson, Fatima Bosch, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Published 2017-08-01

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.

by Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh K Baboota, Stephanie Heasman, Christopher Church, Ivet Elias, Fatima Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
Published 2021-01-01

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

by Jenny M. Hoffmann, John R. Grünberg, Ann Hammarstedt, Tobias Kroon, Thomas U. Greiner, Stefanie Maurer, Ivet Elias, Vilborg Palsdottir, Fatima Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Published 2020-02-01

Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

by Felicia Ranta, Johannes Leveringhaus, Dorothea Theilig, Gabriele Schulz-Raffelt, Anita M Hennige, Dominic G Hildebrand, René Handrick, Verena Jendrossek, Fatima Bosch, Klaus Schulze-Osthoff, Hans-Ulrich Häring, Susanne Ullrich
Published 2011-01-01

Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC

by Sara Marcó, Anna Pujol, Carles Roca, Sandra Motas, Albert Ribera, Miguel Garcia, Maria Molas, Pilar Villacampa, Cristian S. Melia, Víctor Sánchez, Xavier Sánchez, Joan Bertolin, Jesús Ruberte, Virginia Haurigot, Fatima Bosch
Published 2016-09-01

Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs

by Maria Luisa Jaén, Laia Vilà, Ivet Elias, Veronica Jimenez, Jordi Rodó, Luca Maggioni, Rafael Ruiz-de Gopegui, Miguel Garcia, Sergio Muñoz, David Callejas, Eduard Ayuso, Tura Ferré, Iris Grifoll, Anna Andaluz, Jesus Ruberte, Virginia Haurigot, Fatima Bosch
Published 2017-09-01

Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone

by Marita Westhrin, Toril Holien, Muhammad Zahoor, Siv Helen Moen, Glenn Buene, Berit Størdal, Hanne Hella, Huipin Yuan, Joost D deBruijn, Anton Martens, Richard WJ Groen, Fatima Bosch, Ulf Smith, Anne‐Marit Sponaas, Anders Sundan, Therese Standal
Published 2020-01-01

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

by Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Published 2013-01-01

Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy

by Joan Bertolin, Víctor Sánchez, Albert Ribera, Maria Luisa Jaén, Miquel Garcia, Anna Pujol, Xavier Sánchez, Sergio Muñoz, Sara Marcó, Jennifer Pérez, Gemma Elias, Xavier León, Carles Roca, Veronica Jimenez, Pedro Otaegui, Francisca Mulero, Marc Navarro, Jesús Ruberte, Fatima Bosch
Published 2021-09-01

Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

by Alba Navarro-Romero, Anna Vázquez-Oliver, Maria Gomis-González, Carlos Garzón-Montesinos, Rafael Falcón-Moya, Antoni Pastor, Elena Martín-García, Nieves Pizarro, Arnau Busquets-Garcia, Jean-Michel Revest, Pier-Vincenzo Piazza, Fátima Bosch, Mara Dierssen, Rafael de la Torre, Antonio Rodríguez-Moreno, Rafael Maldonado, Andrés Ozaita
Published 2019-05-01

FGF21 gene therapy as treatment for obesity and insulin resistance

by Veronica Jimenez, Claudia Jambrina, Estefania Casana, Victor Sacristan, Sergio Muñoz, Sara Darriba, Jordi Rodó, Cristina Mallol, Miquel Garcia, Xavier León, Sara Marcó, Albert Ribera, Ivet Elias, Alba Casellas, Ignasi Grass, Gemma Elias, Tura Ferré, Sandra Motas, Sylvie Franckhauser, Francisca Mulero, Marc Navarro, Virginia Haurigot, Jesus Ruberte, Fatima Bosch
Published 2018-08-01