BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

by Jenny M. Hoffmann, John R. Grünberg, Christopher Church, Ivet Elias, Vilborg Palsdottir, John-Olov Jansson, Fatima Bosch, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith
Published 2017-08-01

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.

by Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh K Baboota, Stephanie Heasman, Christopher Church, Ivet Elias, Fatima Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
Published 2021-01-01

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

by Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Published 2013-01-01

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

by Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Published 2021-03-01