A Transcriptomic Meta-Analysis Shows Lipid Metabolism Dysregulation as an Early Pathological Mechanism in the Spinal Cord of SOD1 Mice

by Luis C. Fernández-Beltrán, Juan Miguel Godoy-Corchuelo, Maria Losa-Fontangordo, Debbie Williams, Jorge Matias-Guiu, Silvia Corrochano
Published 2021-09-01

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

by Apoorva Mulay, Derek W. Hood, Debbie Williams, Catherine Russell, Steve D. M. Brown, Lynne Bingle, Michael Cheeseman, Colin D. Bingle
Published 2018-02-01

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse

by Derek Hood, Richard Moxon, Tom Purnell, Caroline Richter, Debbie Williams, Ali Azar, Michael Crompton, Sara Wells, Martin Fray, Steve D. M. Brown, Michael T. Cheeseman
Published 2016-01-01

Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity

by Ashleigh G. Wilcox, R. Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L. Oliver, Elizabeth S. Maywood, Michael H. Hastings, Gareth Banks, Patrick M. Nolan
Published 2021-10-01

An in vitro model of murine middle ear epithelium

by Apoorva Mulay, Khondoker M. Akram, Debbie Williams, Hannah Armes, Catherine Russell, Derek Hood, Stuart Armstrong, James P. Stewart, Steve D. M. Brown, Lynne Bingle, Colin D. Bingle
Published 2016-11-01

Transcript Analysis Reveals a Hypoxic Inflammatory Environment in Human Chronic Otitis Media With Effusion

by Mahmood F. Bhutta, Jane Lambie, Lindsey Hobson, Debbie Williams, Hayley E. Tyrer, George Nicholson, Steve D.M. Brown, Helen Brown, Chiara Piccinelli, Guillaume Devailly, James Ramsden, Michael T. Cheeseman
Published 2020-02-01

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.

by Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield
Published 2009-09-01

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.

by Michael T Cheeseman, Hayley E Tyrer, Debbie Williams, Tertius A Hough, Paras Pathak, Maria R Romero, Helen Hilton, Sulzhan Bali, Andrew Parker, Lucie Vizor, Tom Purnell, Kate Vowell, Sara Wells, Mahmood F Bhutta, Paul K Potter, Steve D M Brown
Published 2011-10-01

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.

by Michael Crompton, Tom Purnell, Hayley E Tyrer, Andrew Parker, Greg Ball, Rachel E Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H Dean, Michelle M Simon, Ann-Marie Mallon, Sara Wells, Mahmood F Bhutta, Martin J Burton, Hilda Tateossian, Steve D M Brown
Published 2017-08-01

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

by Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T Neil Dear
Published 2010-06-01

Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function

by Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl
Published 2019-09-01