Lipid–Saporin Nanoparticles for the Intracellular Delivery of Cytotoxic Protein to Overcome ABC Transporter-Mediated Multidrug Resistance In Vitro and In Vivo

by Guan-Nan Zhang, Pranav Gupta, Ming Wang, Anna Maria Barbuti, Charles R. Ashby, Yun-Kai Zhang, Leli Zeng, Qiaobing Xu, Ying-Fang Fan, Zhe-Sheng Chen
Published 2020-02-01

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

by Yuqi Yang, Ning Ji, Chao‐Yun Cai, Jing‐Quan Wang, Zi‐Ning Lei, Qiu‐Xu Teng, Zhuo‐Xun Wu, Qingbin Cui, Yihang Pan, Zhe‐Sheng Chen
Published 2020-07-01

Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar.

by Yue-Li Sun, Jun-Jiang Chen, Priyank Kumar, Kang Chen, Kamlesh Sodani, Atish Patel, Yang-Lu Chen, Si-Dong Chen, Wen-Qi Jiang, Zhe-Sheng Chen
Published 2013-01-01

Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells

by Pranav Gupta, Yun-Kai Zhang, Xiao-Yu Zhang, Yi-Jun Wang, Kimberly W. Lu, Timothy Hall, Richard Peng, Dong-Hua Yang, Ni Xie, Zhe-Sheng Chen
Published 2018-02-01

Correction: Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10)

by Tong Shen, Ye-Hong Kuang, Charles R. Ashby, Yu Lei, Angel Chen, Ying Zhou, Xiang Chen, Amit K. Tiwari, Elizabeth Hopper-Borge, Jiangyong Ouyang, Zhe-Sheng Chen
Published 2009-01-01

Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells

by Jingqiu Wang, Dong-Hua Yang, Yuqi Yang, Jing-Quan Wang, Chao-Yun Cai, Zi-Ning Lei, Qiu-Xu Teng, Zhuo-Xun Wu, Linguo Zhao, Zhe-Sheng Chen
Published 2020-02-01

The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo

by Yan Wen, Ruiqiang Zhao, Pranav Gupta, Yingfang Fan, Yunkai Zhang, Zhenguang Huang, Xiaohui Li, Yuangang Su, Lijuan Liao, Yu-An Xie, Donghua Yang, Zhe-Sheng Chen, Gang Liang
Published 2019-03-01

Esters of the Marine-Derived Triterpene Sipholenol A Reverse P-GP-Mediated Drug Resistance

by Yongchao Zhang, Yun-Kai Zhang, Yi-Jun Wang, Saurabh G. Vispute, Sandeep Jain, Yangmin Chen, Jessalyn Li, Diaa T. A. Youssef, Khalid A. El Sayed, Zhe-Sheng Chen
Published 2015-04-01

Correction: Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10).

by Tong Shen, Ye-Hong Kuang, Charles R. Ashby, Yu Lei, Angel Chen, Ying Zhou, Xiang Chen, Amit K. Tiwari, Elizabeth Hopper-Borge, Jiangyong Ouyang, Zhe-Sheng Chen
Published 2009-01-01

Establishment and characterization of arsenic trioxide resistant KB/ATO cells

by Yun-Kai Zhang, Chunling Dai, Chun-gang Yuan, Hsiang-Chun Wu, Zhijie Xiao, Zi-Ning Lei, Dong-Hua Yang, X. Chris Le, Liwu Fu, Zhe-Sheng Chen
Published 2017-09-01

Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance

by Zhuo-Xun Wu, Yuqi Yang, Qiu-Xu Teng, Jing-Quan Wang, Zi-Ning Lei, Jing-Qiu Wang, Sabrina Lusvarghi, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-01-01

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

by Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Zi-Ning Lei, Jing-Quan Wang, Pranav Gupta, Qiu-Xu Teng, Zhe-Sheng Chen, Dexin Kong, Dong-Hua Yang
Published 2018-10-01

Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

by Xiaofang Luo, Qiu-Xu Teng, Jin-Yun Dong, Dong-Hua Yang, Meifeng Wang, Wubliker Dessie, Jiang-Jiang Qin, Zi-Ning Lei, Jing-Quan Wang, Zuodong Qin, Zhe-Sheng Chen
Published 2020-08-01

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro

by Yuqi Yang, Ning Ji, Ning Ji, Qiu-Xu Teng, Chao-Yun Cai, Jing-Quan Wang, Zhuo-Xun Wu, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen
Published 2020-05-01

Application of microfluidic chips in anticancer drug screening

by Xin-yue Fan, Zhuo-fen Deng, Yan-yan Yan, Valerii E. Orel, Andrii Shypko, Valerii B. Orel, Donika Ivanova, Christian Pilarsky, Jing Tang, Zhe-Sheng Chen, Jian-ye Zhang
Published 2021-09-01

A Small Molecule Inhibitor, OGP46, Is Effective against Imatinib-Resistant BCR-ABL Mutations via the BCR-ABL/JAK-STAT Pathway

by Liuya Wei, Yang Yang, Pranav Gupta, Aihong Wang, Min Zhao, Yao Zhao, Mei Qu, Yu Ke, Ying Liu, Hong-Min Liu, Xin Xu, Yanli Sun, Zhe-Sheng Chen, Zhenbo Hu
Published 2020-09-01

M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells

by Zhuo-Xun Wu, Zheng Peng, Yuqi Yang, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Yi-Ge Fu, Ketankumar Patel, Lili Liu, Lizhu Lin, Chang Zou, Zhe-Sheng Chen
Published 2020-05-01

Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

by Xing-Duo Dong, Meng Zhang, Meng Zhang, Xiubin Ma, Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Yi-Dong Li, Lusheng Lin, Weiguo Feng, Weiguo Feng, Zhe-Sheng Chen
Published 2020-08-01

Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer

by Wenjing Wang, Mengyue Zhao, Lijuan Cui, Yong Ren, Jingyuan Zhang, Junli Chen, Lina Jia, Jiayu Zhang, Jingyu Yang, Guoliang Chen, Charles R. Ashby, Chunfu Wu, Zhe-Sheng Chen, Lihui Wang
Published 2020-09-01

Methyl-Cantharidimide (MCA) Has Anticancer Efficacy in ABCB1- and ABCG2-Overexpressing and Cisplatin Resistant Cancer Cells

by Yi-Dong Li, Yong Mao, Xing-Duo Dong, Zi-Ning Lei, Yuqi Yang, Lizhu Lin, Charles R. Ashby, Dong-Hua Yang, Ying-Fang Fan, Ying-Fang Fan, Zhe-Sheng Chen
Published 2020-06-01