Drug resistance: from bacteria to cancer

by Harsh Patel, Zhuo-Xun Wu, Yanglu Chen, Letao Bo, Zhe-Sheng Chen
Published 2021-09-01

Exploration of Antibiotic Activity of Aminoglycosides, in Particular Ribostamycin Alone and in Combination With Ethylenediaminetetraacetic Acid Against Pathogenic Bacteria

by Jing Kong, Zhuo-Xun Wu, Liuya Wei, Liuya Wei, Zhe-Sheng Chen, Sabesan Yoganathan
Published 2020-07-01

Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line

by Zhuo-Xun Wu, Yuqi Yang, Leli Zeng, Leli Zeng, Harsh Patel, Letao Bo, Lusheng Lin, Zhe-Sheng Chen
Published 2021-02-01

Overexpression of ABCC1 Confers Drug Resistance to Betulin

by Xuan-Yu Chen, Xuan-Yu Chen, Yuqi Yang, Jing-Quan Wang, Zhuo-Xun Wu, Jing Li, Zhe-Sheng Chen
Published 2021-02-01

Overexpression of human ATP-binding cassette transporter ABCG2 contributes to reducing the cytotoxicity of GSK1070916 in cancer cells

by Zhuo-Xun Wu, Qiuyan Mai, Yuqi Yang, Jing-Quan Wang, Hansu Ma, Leli Zeng, Zhe-Sheng Chen, Yihang Pan
Published 2021-04-01

Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor

by Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Silpa Narayanan, Zi-Ning Lei, Qiu-Xu Teng, Leli Zeng, Leli Zeng, Zhe-Sheng Chen
Published 2021-07-01

Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells

by Yongchao Zhang, Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Jun Li, Zoey Sun, Qiu-Xu Teng, Charles R. Ashby, Dong-Hua Yang
Published 2020-11-01

Establishment and Characterization of a Novel Multidrug Resistant Human Ovarian Cancer Cell Line With Heterogenous MRP7 Overexpression

by Jing-Quan Wang, Zhuo-Xun Wu, Yuqi Yang, Jin-Sui Li, Dong-Hua Yang, Ying-Fang Fan, Ying-Fang Fan, Zhe-Sheng Chen
Published 2021-09-01

The Discovery of Novel BCR-ABL Tyrosine Kinase Inhibitors Using a Pharmacophore Modeling and Virtual Screening Approach

by Ting-Ting Huang, Xin Wang, Shao-Jia Qiang, Zhen-Nan Zhao, Zhuo-Xun Wu, Charles R. Ashby, Jia-Zhong Li, Zhe-Sheng Chen
Published 2021-03-01

The Novel benzamide Derivative, VKNG-2, Restores the Efficacy of Chemotherapeutic Drugs in Colon Cancer Cell Lines by Inhibiting the ABCG2 Transporter

by Silpa Narayanan, Nehaben A. Gujarati, Jing-Quan Wang, Zhuo-Xun Wu, Jagadish Koya, Qingbin Cui, Vijaya L. Korlipara, Charles R. Ashby, Zhe-Sheng Chen
Published 2021-02-01

Elevated ABCB1 Expression Confers Acquired Resistance to Aurora Kinase Inhibitor GSK-1070916 in Cancer Cells

by Zhuo-Xun Wu, Yuqi Yang, Jing-Quan Wang, Wen-Min Zhou, Junyu Chen, Yi-Ge Fu, Ketankumar Patel, Zhe-Sheng Chen, Jian-Ye Zhang
Published 2021-01-01

Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway

by Xiaozhong Liao, Lanting Tao, Wei Guo, Zhuo-Xun Wu, Haiyan Du, Jing Wang, Jue Zhang, Hanrui Chen, Zhe-Sheng Chen, Lizhu Lin, Lingling Sun
Published 2020-09-01

OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

by Yuqi Yang, Zhuo-Xun Wu, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang
Published 2021-02-01

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

by Yuqi Yang, Ning Ji, Chao‐Yun Cai, Jing‐Quan Wang, Zi‐Ning Lei, Qiu‐Xu Teng, Zhuo‐Xun Wu, Qingbin Cui, Yihang Pan, Zhe‐Sheng Chen
Published 2020-07-01

Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells

by Jingqiu Wang, Dong-Hua Yang, Yuqi Yang, Jing-Quan Wang, Chao-Yun Cai, Zi-Ning Lei, Qiu-Xu Teng, Zhuo-Xun Wu, Linguo Zhao, Zhe-Sheng Chen
Published 2020-02-01

Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance

by Zhuo-Xun Wu, Yuqi Yang, Qiu-Xu Teng, Jing-Quan Wang, Zi-Ning Lei, Jing-Qiu Wang, Sabrina Lusvarghi, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-01-01

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro

by Yuqi Yang, Ning Ji, Ning Ji, Qiu-Xu Teng, Chao-Yun Cai, Jing-Quan Wang, Zhuo-Xun Wu, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen
Published 2020-05-01

M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells

by Zhuo-Xun Wu, Zheng Peng, Yuqi Yang, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Yi-Ge Fu, Ketankumar Patel, Lili Liu, Lizhu Lin, Chang Zou, Zhe-Sheng Chen
Published 2020-05-01

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

by Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong
Published 2019-06-01

Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells

by Weiguo Feng, Weiguo Feng, Meng Zhang, Meng Zhang, Zhuo-Xun Wu, Jing-Quan Wang, Xing-Duo Dong, Yuqi Yang, Qiu-Xu Teng, Xuan-Yu Chen, Xuan-Yu Chen, Qingbin Cui, Dong-Hua Yang
Published 2020-06-01