Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10).

by Tong Shen, Ye-Hong Kuang, Charles R Ashby, Yu Lei, Angel Chen, Ying Zhou, Xiang Chen, Amit K Tiwari, Amit K Tiwari, Elizabeth Hopper-Borge, Jiangyong Ouyang, Zhe-Sheng Chen
Published 2009-10-01

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

by Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong
Published 2019-06-01

VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study

by Silpa Narayanan, Ying-Fang Fan, Nehaben A. Gujarati, Qiu-Xu Teng, Jing-Quan Wang, Chao-Yun Cai, Yuqi Yang, Anirudh J. Chintalapati, Yixiong Lei, Vijaya L. Korlipara, Zhe-Sheng Chen
Published 2021-09-01

Cabozantinib Reverses Topotecan Resistance in Human Non-Small Cell Lung Cancer NCI-H460/TPT10 Cell Line and Tumor Xenograft Model

by Zi-Ning Lei, Qiu-Xu Teng, Pranav Gupta, Wei Zhang, Wei Zhang, Silpa Narayanan, Dong-Hua Yang, John N. D. Wurpel, Ying-Fang Fan, Ying-Fang Fan, Zhe-Sheng Chen
Published 2021-03-01

Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor

by Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Ning Ji, Qingbin Cui, Qingbin Cui, Han Fu, Lizhu Lin, Dong-Hua Yang, Ying-Fang Fan, Ying-Fang Fan, Zhe-Sheng Chen
Published 2020-12-01

Y6, an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance

by Rui-Qiang Zhao, Rui-Qiang Zhao, Rui-Qiang Zhao, Yan Wen, Yan Wen, Pranav Gupta, Zi-Ning Lei, Chao-Yun Cai, Gang Liang, Dong-Hua Yang, Zhe-Sheng Chen, Yu-An Xie
Published 2019-01-01

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

by Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Chao-Yun Cai, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Leli Zeng, Leli Zeng, Pranav Gupta, Zhe-Sheng Chen
Published 2018-10-01

B4G2 Induces Mitochondrial Apoptosis by the ROS-Mediated Opening of Ca2+-Dependent Permeability Transition Pores

by Nan Yao, Ying-Jie Li, Dong-Mei Zhang, Dao-Lu Liu, Ming-Kuen Tang, Anita Yiu, Yong Li, Wei-Min Chen, Ping Lan, Zhe Yao, Zhe-Sheng Chen, Wen-Cai Ye
Published 2015-09-01

BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells.

by Dan He, Xiao-qin Zhao, Xing-gui Chen, Yi Fang, Satyakam Singh, Tanaji T Talele, Hui-juan Qiu, Yong-ju Liang, Xiao-kun Wang, Guo-qing Zhang, Zhe-sheng Chen, Li-wu Fu
Published 2013-01-01

NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance

by Meng Zhang, Meng Zhang, Xuan-Yu Chen, Xuan-Yu Chen, Xing-Duo Dong, Jing-Quan Wang, Weiguo Feng, Weiguo Feng, Qiu-Xu Teng, Qingbin Cui, Jing Li, Xiang-Qi Li, Zhe-Sheng Chen
Published 2020-07-01

Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

by Jingqiu Wang, Jingqiu Wang, Jing-Quan Wang, Chao-Yun Cai, Qingbin Cui, Qingbin Cui, Yuqi Yang, Zhuo-Xun Wu, Xingduo Dong, Leli Zeng, Leli Zeng, Linguo Zhao, Dong-Hua Yang, Zhe-Sheng Chen
Published 2020-02-01

Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter

by Hai-Ling Gao, Hai-Ling Gao, Pranav Gupta, Qingbin Cui, Yunali V. Ashar, Zhuo-Xun Wu, Leli Zeng, Leli Zeng, Zi-Ning Lei, Qiu-Xu Teng, Charles R. Ashby, Yingjun Guan, Zhe-Sheng Chen
Published 2020-10-01

Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

by Qingbin Cui, Qingbin Cui, Chao-Yun Cai, Hai-Ling Gao, Hai-Ling Gao, Liang Ren, Ning Ji, Ning Ji, Pranav Gupta, Yuqi Yang, Suneet Shukla, Suresh V. Ambudkar, Dong-Hua Yang, Zhe-Sheng Chen
Published 2019-04-01

bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10).

by Jun-Jiang Chen, Atish Patel, Kamlesh Sodani, Zhi-Jie Xiao, Amit K Tiwari, Amit K Tiwari, Dong-Mei Zhang, Ying-Jie Li, Dong-Hua Yang, Wen-Cai Ye, Si-Dong Chen, Zhe-Sheng Chen
Published 2013-01-01

The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.

by Pei-Rong Ding, Amit K Tiwari, Amit K Tiwari, Shinobu Ohnuma, Jeferson W K K Lee, Xin An, Chun-Ling Dai, Qi-Si Lu, Satyakam Singh, Dong-Hua Yang, Tanaji T Talele, Suresh V Ambudkar, Zhe-Sheng Chen
Published 2011-04-01

Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing

by Xiaoshi Ma, Jinan Guo, Kaisheng Liu, Lipeng Chen, Dale Liu, Shaowei Dong, Jinquan Xia, Qiaoyun Long, Yongjian Yue, Pan Zhao, Fengyan Hu, Zhangang Xiao, Xinghua Pan, Kefeng Xiao, Zhiqiang Cheng, Zunfu Ke, Zhe-Sheng Chen, Chang Zou
Published 2020-10-01

Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1

by Wei Liu, Wei Liu, Sheng-Xiong Zhang, Bo Ai, Hua-Feng Pan, Dan Zhang, Yu Jiang, Lei-Hao Hu, Lei-Hao Hu, Ling-Ling Sun, Ling-Ling Sun, Zhe-Sheng Chen, Li-Zhu Lin, Li-Zhu Lin
Published 2021-09-01

Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line

by Zi-Ning Lei, Qiu-Xu Teng, Wei Zhang, Wei Zhang, Ying-Fang Fan, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Kimberly W. Lu, Kimberly W. Lu, Dong-Hua Yang, John N. D. Wurpel, Zhe-Sheng Chen
Published 2020-12-01

OGP46 Induces Differentiation of Acute Myeloid Leukemia Cells via Different Optimal Signaling Pathways

by Min Zhao, Min Zhao, Jiangyun Wang, Jiangyun Wang, Mei Qu, Mei Qu, Yao Zhao, Haihua Wang, Yu Ke, Ying Liu, Zi-Ning Lei, Zi-Ning Lei, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Liuya Wei, Zhe-Sheng Chen
Published 2021-03-01

AZ32 Reverses ABCG2-Mediated Multidrug Resistance in Colorectal Cancer

by Kun Liu, Yan-Chi Li, Yu Chen, Xiao-Bao Shi, Zi-Hao Xing, Zheng-Jie He, Sheng-Te Wang, Wei-Jing Liu, Peng-Wei Zhang, Ze-Zhong Yu, Xue-Mei Mo, Mei-Wan Chen, Zhe-Sheng Chen, Zhi Shi
Published 2021-05-01