Bioinformatics Biology Conformations Degrees of freedom (mechanics) Electric fields Embeddings Free energy Free energy landscape Image reconstruction Images reconstruction Imaging Kernel-methods Learning systems Manifold Manifold embedding Manifolds Medical imaging Principal component analysis Principal-component analysis Proteins Quantitative biology Single particle cryogenic microscopy Single-particle Spectral geometry Three dimensional displays Three-dimensional display Three-dimensional displays Unsupervised machine learning biomolecules free-energy landscape