Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

by Tyler E. Mattox, Xi Chen, Yulia Y. Maxuitenko, Adam B. Keeton, Gary A. Piazza
Published 2019-12-01

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.

by Mohamed I Attia, Wagdy M Eldehna, Samar A Afifi, Adam B Keeton, Gary A Piazza, Hatem A Abdel-Aziz
Published 2017-01-01

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

by Wagdy M. Eldehna, Reem I. Al-Wabli, Maha S. Almutairi, Adam B. Keeton, Gary A. Piazza, Hatem A. Abdel-Aziz, Mohamed I. Attia
Published 2018-01-01

NSAIDs: Old Drugs Reveal New Anticancer Targets

by Gary A. Piazza, Adam B. Keeton, Heather N. Tinsley, Jason D. Whitt, Bernard D. Gary, Bini Mathew, Raj Singh, William E. Grizzle, Robert C. Reynolds
Published 2010-05-01

Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS

by Antonio B. Ward, Adam B. Keeton, Xi Chen, Tyler E. Mattox, Alex B. Coley, Yulia Y. Maxuitenko, Donald J. Buchsbaum, Troy D. Randall, Gang Zhou, Gary A. Piazza
Published 2020-09-01

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

by Aikaterini Emmanouilidi, Ilaria Casari, Begum Gokcen Akkaya, Tania Maffucci, Luc Furic, Federica Guffanti, Massimo Broggini, Xi Chen, Yulia Y. Maxuitenko, Adam B. Keeton, Gary A. Piazza, Kenneth J. Linton, Marco Falasca
Published 2020-07-01

Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

by Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J. Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B. Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A. Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasca
Published 2019-08-01

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule The...

by W Joon Chung, Jennifer L Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M Rowe, Zackery E Plyler, Jeong S Hong, Marina Mazur, Gary A Piazza, Adam B Keeton, E Lucile White, Lynn Rasmussen, Allan M Weissman, R Aldrin Denny, Jeffrey L Brodsky, Eric J Sorscher
Published 2016-01-01