Amides Article Catalytic Domain Crystal structure Enzyme Inhibitors Epoxide Hydrolases Epoxide hydrolase Hypocrea jecorina IC50 Inhibitors Inhibitory Concentration 50 Models, Molecular Trichoderma Trichoderma reesei Urea amide antagonists and inhibitors antifungal agent chemistry crystallography drug design drug effect enzyme active site enzyme conformation enzyme inhibitor enzymology epoxide hydrolase fungal metabolism fungal virulence human