Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

by Ake T. Lu, Eilis Hannon, Morgan E. Levine, Eileen M. Crimmins, Katie Lunnon, Jonathan Mill, Daniel H. Geschwind, Steve Horvath
Published 2017-05-01

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

by Ake T. Lu, Eilis Hannon, Morgan E. Levine, Ke Hao, Eileen M. Crimmins, Katie Lunnon, Alexey Kozlenkov, Jonathan Mill, Stella Dracheva, Steve Horvath
Published 2016-02-01

Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins

by Todd R. Robeck, Zhe Fei, Ake T. Lu, Amin Haghani, Eve Jourdain, Joseph A. Zoller, Caesar Z. Li, Karen J. Steinman, Stacy DiRocco, Todd Schmitt, Steve Osborn, Bill Van Bonn, Etsuko Katsumata, June Mergl, Javier Almunia, Magdalena Rodriguez, Martin Haulena, Christopher Dold, Steve Horvath
Published 2021-05-01

Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci

by Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Published 2021-07-01

A meta-analysis of genome-wide association studies of epigenetic age acceleration.

by Jude Gibson, Tom C Russ, Toni-Kim Clarke, David M Howard, Robert F Hillary, Kathryn L Evans, Rosie M Walker, Mairead L Bermingham, Stewart W Morris, Archie Campbell, Caroline Hayward, Alison D Murray, David J Porteous, Steve Horvath, Ake T Lu, Andrew M McIntosh, Heather C Whalley, Riccardo E Marioni
Published 2019-11-01

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models

by Ake T. Lu, Pritika Narayan, Matthew J. Grant, Peter Langfelder, Nan Wang, Seung Kwak, Hilary Wilkinson, Richard Z. Chen, Jian Chen, C. Simon Bawden, Skye R. Rudiger, Marc Ciosi, Afroditi Chatzi, Alastair Maxwell, Timothy A. Hore, Jeff Aaronson, Jim Rosinski, Alicia Preiss, Thomas F. Vogt, Giovanni Coppola, Darren Monckton, Russell G. Snell, X. William Yang, Steve Horvath
Published 2020-09-01

DNA methylation predicts age and provides insight into exceptional longevity of bats

by Gerald S. Wilkinson, Danielle M. Adams, Amin Haghani, Ake T. Lu, Joseph Zoller, Charles E. Breeze, Bryan D. Arnold, Hope C. Ball, Gerald G. Carter, Lisa Noelle Cooper, Dina K. N. Dechmann, Paolo Devanna, Nicolas J. Fasel, Alexander V. Galazyuk, Linus Günther, Edward Hurme, Gareth Jones, Mirjam Knörnschild, Ella Z. Lattenkamp, Caesar Z. Li, Frieder Mayer, Josephine A. Reinhardt, Rodrigo A. Medellin, Martina Nagy, Brian Pope, Megan L. Power, Roger D. Ransome, Emma C. Teeling, Sonja C. Vernes, Daniel Zamora-Mejías, Joshua Zhang, Paul A. Faure, Lucas J. Greville, Steve Horvath
Published 2021-03-01

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

by Ake T. Lu, Luting Xue, Elias L. Salfati, Brian H. Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M. Murabito, Douglas P. Kiel, Pei-Chien Tsai, Idil Yet, Jordana T. Bell, Massimo Mangino, Toshiko Tanaka, Allan F. McRae, Riccardo E. Marioni, Peter M. Visscher, Naomi R. Wray, Ian J. Deary, Morgan E. Levine, Austin Quach, Themistocles Assimes, Philip S. Tsao, Devin Absher, James D. Stewart, Yun Li, Alex P. Reiner, Lifang Hou, Andrea A. Baccarelli, Eric A. Whitsel, Abraham Aviv, Alexia Cardona, Felix R. Day, Nicholas J. Wareham, John R. B. Perry, Ken K. Ong, Kenneth Raj, Kathryn L. Lunetta, Steve Horvath
Published 2018-01-01

Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats

by Gerald S. Wilkinson, Danielle M. Adams, Amin Haghani, Ake T. Lu, Joseph Zoller, Charles E. Breeze, Bryan D. Arnold, Hope C. Ball, Gerald G. Carter, Lisa Noelle Cooper, Dina K. N. Dechmann, Paolo Devanna, Nicolas J. Fasel, Alexander V. Galazyuk, Linus Günther, Edward Hurme, Gareth Jones, Mirjam Knörnschild, Ella Z. Lattenkamp, Caesar Z. Li, Frieder Mayer, Josephine A. Reinhardt, Rodrigo A. Medellin, Martina Nagy, Brian Pope, Megan L. Power, Roger D. Ransome, Emma C. Teeling, Sonja C. Vernes, Daniel Zamora-Mejías, Joshua Zhang, Paul A. Faure, Lucas J. Greville, Steve Horvath, L. Gerardo Herrera M., José J. Flores-Martínez
Published 2021-05-01

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

by Daniel L. McCartney, Josine L. Min, Rebecca C. Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Seyma Katrinli, Pei-Lun Kuo, Pamela R. Matias-Garcia, Pashupati P. Mishra, Marianne Nygaard, Teemu Palviainen, Amit Patki, Laura M. Raffield, Scott M. Ratliff, Tom G. Richardson, Oliver Robinson, Mette Soerensen, Dianjianyi Sun, Pei-Chien Tsai, Matthijs D. van der Zee, Rosie M. Walker, Xiaochuan Wang, Yunzhang Wang, Rui Xia, Zongli Xu, Jie Yao, Wei Zhao, Adolfo Correa, Eric Boerwinkle, Pierre-Antoine Dugué, Peter Durda, Hannah R. Elliott, Christian Gieger, The Genetics of DNA Methylation Consortium, Eco J. C. de Geus, Sarah E. Harris, Gibran Hemani, Medea Imboden, Mika Kähönen, Sharon L. R. Kardia, Jacob K. Kresovich, Shengxu Li, Kathryn L. Lunetta, Massimo Mangino, Dan Mason, Andrew M. McIntosh, Jonas Mengel-From, Ann Zenobia Moore, Joanne M. Murabito, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Miina Ollikainen, James S. Pankow, Nancy L. Pedersen, Annette Peters, Silvia Polidoro, David J. Porteous, Olli Raitakari, Stephen S. Rich, Dale P. Sandler, Elina Sillanpää, Alicia K. Smith, Melissa C. Southey, Konstantin Strauch, Hemant Tiwari, Toshiko Tanaka, Therese Tillin, Andre G. Uitterlinden, David J. Van Den Berg, Jenny van Dongen, James G. Wilson, John Wright, Idil Yet, Donna Arnett, Stefania Bandinelli, Jordana T. Bell, Alexandra M. Binder, Dorret I. Boomsma, Wei Chen, Kaare Christensen, Karen N. Conneely, Paul Elliott, Luigi Ferrucci, Myriam Fornage, Sara Hägg, Caroline Hayward, Marguerite Irvin, Jaakko Kaprio, Deborah A. Lawlor, Terho Lehtimäki, Falk W. Lohoff, Lili Milani, Roger L. Milne, Nicole Probst-Hensch, Alex P. Reiner, Beate Ritz, Jerome I. Rotter, Jennifer A. Smith, Jack A. Taylor, Joyce B. J. van Meurs, Paolo Vineis, Melanie Waldenberger, Ian J. Deary, Caroline L. Relton, Steve Horvath, Riccardo E. Marioni
Published 2021-06-01