Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape.

by Sara Hamis, Mohammad Kohandel, Ludwig J Dubois, Ala Yaromina, Philippe Lambin, Gibin G Powathil
Published 2020-08-01

Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis

by Eloy Moreno Roig, Ala Yaromina, Ruud Houben, Arjan J. Groot, Ludwig Dubois, Marc Vooijs
Published 2018-06-01

Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy

by Damiënne Marcus, Relinde I. Y. Lieverse, Carmen Klein, Amir Abdollahi, Philippe Lambin, Ludwig J. Dubois, Ala Yaromina
Published 2021-03-01

Human fibronectin extra domain B as a biomarker for targeted therapy in cancer

by Relinde I. Y. Lieverse, Damiënne Marcus, Alexander M. A. van derWiel, Evert J. Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois
Published 2020-07-01

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

by Linda Spiegelberg, Ruud Houben, Raymon Niemans, Dirk de Ruysscher, Ala Yaromina, Jan Theys, Christopher P. Guise, Jeffrey B. Smaill, Adam V. Patterson, Philippe Lambin, Ludwig J. Dubois
Published 2019-02-01

Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

by Venus Sosa Iglesias, Jan Theys, Arjan J. Groot, Lydie M. O. Barbeau, Alyssa Lemmens, Ala Yaromina, Mario Losen, Ruud Houben, Ruud Houben, Ludwig Dubois, Marc Vooijs, Marc Vooijs
Published 2018-11-01

Hypoxia PET Imaging with [18F]-HX4—A Promising Next-Generation Tracer

by Sebastian Sanduleanu, Alexander M.A. van der Wiel, Relinde I.Y. Lieverse, Damiënne Marcus, Abdalla Ibrahim, Sergey Primakov, Guangyao Wu, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin
Published 2020-05-01

Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

by Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Published 2021-03-01

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

by Nicolle H. Rekers, Veronica Olivo Pimentel, Ala Yaromina, Natasja G. Lieuwes, Rianne Biemans, Catharina M. L. Zegers, Wilfred T. V. Germeraad, Evert J. Van Limbergen, Dario Neri, Ludwig J. Dubois, Philippe Lambin
Published 2018-04-01

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy.

by Simon J A van Kuijk, Roben G Gieling, Raymon Niemans, Natasja G Lieuwes, Rianne Biemans, Brian A Telfer, Guido R M M Haenen, Ala Yaromina, Philippe Lambin, Ludwig J Dubois, Kaye J Williams
Published 2016-01-01

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

by Eloy Moreno Roig, Arjan J. Groot, Ala Yaromina, Tessa C. Hendrickx, Lydie M. O. Barbeau, Lorena Giuranno, Glenn Dams, Jonathan Ient, Veronica Olivo Pimentel, Marike W. van Gisbergen, Ludwig J. Dubois, Marc A. Vooijs
Published 2019-01-01

Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial

by Bart J.T. Reymen, Marike W. van Gisbergen, Aniek J.G. Even, Catharina M.L. Zegers, Marco Das, Erik Vegt, Joachim E. Wildberger, Felix M. Mottaghy, Ala Yaromina, Ludwig J. Dubois, Wouter van Elmpt, Dirk De Ruysscher, Philippe Lambin
Published 2020-03-01

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised contr...

by Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina, Dirk De Ruysscher, Ludwig J. Dubois, Philippe Lambin
Published 2020-06-01