Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways

by Aziz Taghbalout, Menghan Du, Nathaniel Jillette, Wojciech Rosikiewicz, Abhijit Rath, Christopher D. Heinen, Sheng Li, Albert W. Cheng
Published 2019-09-01

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

by Dorothea Maetzel, Sovan Sarkar, Haoyi Wang, Lina Abi-Mosleh, Ping Xu, Albert W. Cheng, Qing Gao, Maisam Mitalipova, Rudolf Jaenisch
Published 2014-06-01

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

by Irina M Shapiro, Albert W Cheng, Nicholas C Flytzanis, Michele Balsamo, John S Condeelis, Maja H Oktay, Christopher B Burge, Frank B Gertler
Published 2011-08-01

SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.

by Michael A Lodato, Christopher W Ng, Joseph A Wamstad, Albert W Cheng, Kevin K Thai, Ernest Fraenkel, Rudolf Jaenisch, Laurie A Boyer
Published 2013-01-01

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

by Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge
Published 2014-11-01