Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.

by Cristiana Lalli, Alessandra Guidi, Nadia Gennari, Sergio Altamura, Alberto Bresciani, Giovina Ruberti
Published 2015-01-01

Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive System...

by Alessandra Guidi, Cristiana Lalli, Emerald Perlas, Giulia Bolasco, Martina Nibbio, Edith Monteagudo, Alberto Bresciani, Giovina Ruberti
Published 2016-08-01

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

by Valentina Fodale, Roberta Pintauro, Manuel Daldin, Roberta Altobelli, Maria Carolina Spiezia, Monica Bisbocci, Douglas Macdonald, Alberto Bresciani
Published 2020-12-01

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

by Alessandra Guidi, Fulvio Saccoccia, Nadia Gennari, Roberto Gimmelli, Emanuela Nizi, Cristiana Lalli, Giacomo Paonessa, Giuliana Papoff, Alberto Bresciani, Giovina Ruberti
Published 2018-12-01

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.

by Alessandra Guidi, Cristiana Lalli, Roberto Gimmelli, Emanuela Nizi, Matteo Andreini, Nadia Gennari, Fulvio Saccoccia, Steven Harper, Alberto Bresciani, Giovina Ruberti
Published 2017-10-01

Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy.

by Alessandra Guidi, Greta Petrella, Valentina Fustaino, Fulvio Saccoccia, Sara Lentini, Roberto Gimmelli, Giulia Di Pietro, Alberto Bresciani, Daniel Oscar Cicero, Giovina Ruberti
Published 2020-10-01

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

by Lorenzo Turcano, Theo Battista, Esther Torrente De Haro, Antonino Missineo, Cristina Alli, Giacomo Paonessa, Gianni Colotti, Steven Harper, Annarita Fiorillo, Andrea Ilari, Alberto Bresciani
Published 2020-05-01

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

by Lorenzo Turcano, Esther Torrente, Antonino Missineo, Matteo Andreini, Marina Gramiccia, Trentina Di Muccio, Ilaria Genovese, Annarita Fiorillo, Steven Harper, Alberto Bresciani, Gianni Colotti, Andrea Ilari
Published 2018-11-01

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

by Elisa Pesce, Annarita Miluzio, Lorenzo Turcano, Claudia Minici, Delia Cirino, Piera Calamita, Nicola Manfrini, Stefania Oliveto, Sara Ricciardi, Renata Grifantini, Massimo Degano, Alberto Bresciani, Stefano Biffo
Published 2020-01-01

Quantifying autophagy using novel LC3B and p62 TR-FRET assays.

by Alberto Bresciani, Maria Carolina Spiezia, Roberto Boggio, Cristina Cariulo, Anja Nordheim, Roberta Altobelli, Kirsten Kuhlbrodt, Celia Dominguez, Ignacio Munoz-Sanjuan, John Wityak, Valentina Fodale, Deanna M Marchionini, Andreas Weiss
Published 2018-01-01

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

by Alessandra Scagliola, Annarita Miluzio, Gabriele Ventura, Stefania Oliveto, Chiara Cordiglieri, Nicola Manfrini, Delia Cirino, Sara Ricciardi, Luca Valenti, Guido Baselli, Roberta D’Ambrosio, Marco Maggioni, Daniela Brina, Alberto Bresciani, Stefano Biffo
Published 2021-08-01

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

by Manuel Daldin, Valentina Fodale, Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi, Maria Carolina Spiezia, Sean M. Deguire, Marta Cherubini, Douglas Macdonald, Andreas Weiss, Alberto Bresciani, Jean-Paul Gerard Vonsattel, Lara Petricca, J. Lawrence Marsh, Silvia Gines, Iolanda Santimone, Massimo Marano, Hilal A. Lashuel, Ferdinando Squitieri, Andrea Caricasole
Published 2017-07-01