Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule

by Edyta Petters, Aleksandra Sokolowska-Wedzina, Jacek Otlewski
Published 2015-08-01

Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.

by Aleksandra Borek, Aleksandra Sokolowska-Wedzina, Grzegorz Chodaczek, Jacek Otlewski
Published 2018-01-01

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

by Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska, Jacek Otlewski
Published 2017-08-01

Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1

by Alicja M. Sochaj-Gregorczyk, Patryk Ludzia, Emilia Kozdrowska, Piotr Jakimowicz, Aleksandra Sokolowska-Wedzina, Jacek Otlewski
Published 2017-08-01

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors

by Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Vigdis Sørensen, Aleksandra Sokolowska-Wedzina, Michal Lobocki, Karolina Weronika Swiderska, Daniel Krowarsch, Antoni Wiedlocha, Jacek Otlewski
Published 2017-07-01

The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells

by Marta Poźniak, Natalia Porębska, Mateusz Adam Krzyścik, Aleksandra Sokołowska-Wędzina, Kamil Jastrzębski, Martyna Sochacka, Jakub Szymczyk, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Published 2021-05-01

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

by Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski
Published 2020-09-01