Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

by Alex N. Zelensky, Joost Schimmel, Hanneke Kool, Roland Kanaar, Marcel Tijsterman
Published 2017-07-01

Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.

by Alex N Zelensky, Mascha Schoonakker, Inger Brandsma, Marcel Tijsterman, Dik C van Gent, Jeroen Essers, Roland Kanaar
Published 2020-01-01

High Resolution View on the Regulation of Recombinase Accumulation in Mammalian Meiosis

by Aditya N. Mhaskar, Lieke Koornneef, Lieke Koornneef, Alex N. Zelensky, Adriaan B. Houtsmuller, Adriaan B. Houtsmuller, Willy M. Baarends
Published 2021-05-01

Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

by Maarten W Paul, Arshdeep Sidhu, Yongxin Liang, Sarah E van Rossum-Fikkert, Hanny Odijk, Alex N Zelensky, Roland Kanaar, Claire Wyman
Published 2021-07-01

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation

by Nathalie van den Tempel, Alex N. Zelensky, Hanny Odijk, Charlie Laffeber, Christine K. Schmidt, Inger Brandsma, Jeroen Demmers, Przemek M. Krawczyk, Roland Kanaar
Published 2019-01-01

BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination

by Rania Ghouil, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, Sari E. van Rossum-Fikkert, Yvette van Loon, Natalia Felipe-Medina, Alberto M. Pendas, Alex Maas, Jeroen Essers, Pierre Legrand, Willy M. Baarends, Roland Kanaar, Sophie Zinn-Justin, Alex N. Zelensky
Published 2021-07-01

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

by Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Nicole van Vliet, Esther Sleddens, Marcel Reuter, Hanny Odijk, Nathalie van den Tempel, Dick H.W. Dekkers, Karel Bezstarosti, Jeroen A.A. Demmers, Alex Maas, Joyce Lebbink, Claire Wyman, Jeroen Essers, Dik C. van Gent, Willy M. Baarends, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky
Published 2019-06-01