Generalized enzymatic mechanism of catalysis by tetrameric l-asparaginases from mesophilic bacteria

by Pawel Strzelczyk, Di Zhang, Marzena Dyba, Alexander Wlodawer, Jacek Lubkowski
Published 2020-10-01

Avoidable errors in deposited macromolecular structures: an impediment to efficient data mining

by Zbigniew Dauter, Alexander Wlodawer, Wladek Minor, Mariusz Jaskolski, Bernhard Rupp
Published 2014-05-01

Crystallographic models of SARS-CoV-2 3CLpro: in-depth assessment of structure quality and validation

by Mariusz Jaskolski, Zbigniew Dauter, Ivan G. Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Bernhard Rupp, Alexander Wlodawer
Published 2021-03-01

New insights into structural and functional relationships between LonA proteases and ClpB chaperones

by Tatyana V. Rotanova, Anna G. Andrianova, Arsen M. Kudzhaev, Mi Li, Istvan Botos, Alexander Wlodawer, Alla Gustchina
Published 2019-09-01

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.

by Jill Glesner, Sabina Wünschmann, Mi Li, Alla Gustchina, Alexander Wlodawer, Martin Himly, Martin D Chapman, Anna Pomés
Published 2011-01-01

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

by Jyoti K. Jha, Mi Li, Rodolfo Ghirlando, Lisa M. Miller Jenkins, Alexander Wlodawer, Dhruba Chattoraj, Gary M. Dunny
Published 2017-04-01

RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes.

by Rui Cruz, Pitter Huesgen, Sean P Riley, Alexander Wlodawer, Carlos Faro, Christopher M Overall, Juan J Martinez, Isaura Simões
Published 2014-08-01

Crystal structures of a plant trypsin inhibitor from Enterolobium contortisiliquum (EcTI) and of its complex with bovine trypsin.

by Dongwen Zhou, Yara A Lobo, Isabel F C Batista, Rafael Marques-Porto, Alla Gustchina, Maria L V Oliva, Alexander Wlodawer
Published 2013-01-01

The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms

by Hannes M. Beyer, Salla I. Virtanen, A. Sesilja Aranko, Kornelia M. Mikula, George T. Lountos, Alexander Wlodawer, O. H. Samuli Ollila, Hideo Iwaï
Published 2020-11-01

Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.

by Elena Gustchina, Mi Li, John M Louis, D Eric Anderson, John Lloyd, Christian Frisch, Carole A Bewley, Alla Gustchina, Alexander Wlodawer, G Marius Clore
Published 2010-11-01

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.

by Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G Marius Clore, Alexander Wlodawer
Published 2013-01-01

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

by Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer
Published 2019-11-01

Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis.

by Elena Peletskaya, Mark Andrake, Alla Gustchina, George Merkel, Jerry Alexandratos, Dongwen Zhou, Ravi S Bojja, Tadashi Satoh, Mikhail Potapov, Alex Kogon, Viktor Potapov, Alexander Wlodawer, Anna Marie Skalka
Published 2011-01-01

Rapid response to emerging biomedical challenges and threats

by Marek Grabowski, Joanna M. Macnar, Marcin Cymborowski, David R. Cooper, Ivan G. Shabalin, Miroslaw Gilski, Dariusz Brzezinski, Marcin Kowiel, Zbigniew Dauter, Bernhard Rupp, Alexander Wlodawer, Mariusz Jaskolski, Wladek Minor
Published 2021-05-01

Crystal Structure of Crataeva tapia Bark Protein (CrataBL) and Its Effect in Human Prostate Cancer Cell Lines.

by Rodrigo da Silva Ferreira, Dongwen Zhou, Joana Gasperazzo Ferreira, Mariana Cristina Cabral Silva, Rosemeire Aparecida Silva-Lucca, Reinhard Mentele, Edgar Julian Paredes-Gamero, Thiago Carlos Bertolin, Maria Tereza Dos Santos Correia, Patrícia Maria Guedes Paiva, Alla Gustchina, Alexander Wlodawer, Maria Luiza Vilela Oliva
Published 2013-01-01

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

by Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Published 2021-01-01