Heritable stochastic switching revealed by single-cell genealogy.

by Benjamin B Kaufmann, Qiong Yang, Jerome T Mettetal, Alexander van Oudenaarden
Published 2007-09-01

Differential Stoichiometry among Core Ribosomal Proteins

by Nikolai Slavov, Stefan Semrau, Edoardo Airoldi, Bogdan Budnik, Alexander van Oudenaarden
Published 2015-11-01

A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.

by Christoph G Engert, Rita Droste, Alexander van Oudenaarden, H Robert Horvitz
Published 2018-04-01

Stochastic cytokine expression induces mixed T helper cell States.

by Miaoqing Fang, Huangming Xie, Stephanie K Dougan, Hidde Ploegh, Alexander van Oudenaarden
Published 2013-07-01

The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.

by Adam M Saffer, Dong Hyun Kim, Alexander van Oudenaarden, H Robert Horvitz
Published 2011-12-01

Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis

by Nikolai Slavov, Bogdan A. Budnik, David Schwab, Edoardo M. Airoldi, Alexander van Oudenaarden
Published 2014-05-01

A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans.

by Hannah S Seidel, Michael Ailion, Jialing Li, Alexander van Oudenaarden, Matthew V Rockman, Leonid Kruglyak
Published 2011-07-01

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

by Stefan Semrau, Johanna E. Goldmann, Magali Soumillon, Tarjei S. Mikkelsen, Rudolf Jaenisch, Alexander van Oudenaarden
Published 2017-10-01

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

by Benedetta Artegiani, Anna Lyubimova, Mauro Muraro, Johan H. van Es, Alexander van Oudenaarden, Hans Clevers
Published 2017-12-01

FuseFISH: Robust Detection of Transcribed Gene Fusions in Single Cells

by Stefan Semrau, Nicola Crosetto, Magda Bienko, Marina Boni, Paolo Bernasconi, Roberto Chiarle, Alexander van Oudenaarden
Published 2014-01-01

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.

by Y Q Shirleen Soh, Jan Philipp Junker, Mark E Gill, Jacob L Mueller, Alexander van Oudenaarden, David C Page
Published 2015-09-01

Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta

by Chloé S. Baron, Lennart Kester, Anna Klaus, Jean-Charles Boisset, Roshana Thambyrajah, Laurent Yvernogeau, Valérie Kouskoff, Georges Lacaud, Alexander van Oudenaarden, Catherine Robin
Published 2018-06-01

Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling.

by Yueh-Chiang Hu, Peter K Nicholls, Y Q Shirleen Soh, Joseph R Daniele, Jan Philipp Junker, Alexander van Oudenaarden, David C Page
Published 2015-03-01

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

by Shilu Amin, Roel Neijts, Salvatore Simmini, Carina van Rooijen, Sander C. Tan, Lennart Kester, Alexander van Oudenaarden, Menno P. Creyghton, Jacqueline Deschamps
Published 2016-12-01

Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

by Maya Sen, Dylan Mooijman, Alex Chialastri, Jean-Charles Boisset, Mina Popovic, Björn Heindryckx, Susana M. Chuva de Sousa Lopes, Siddharth S. Dey, Alexander van Oudenaarden
Published 2021-02-01

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

by Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen
Published 2016-03-01

Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

by Ábel Vértesy, Wibowo Arindrarto, Matthias S. Roost, Björn Reinius, Vanessa Torrens-Juaneda, Monika Bialecka, Ioannis Moustakas, Yavuz Ariyurek, Ewart Kuijk, Hailiang Mei, Rickard Sandberg, Alexander van Oudenaarden, Susana M. Chuva de Sousa Lopes
Published 2018-05-01

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

by Florian Wimmers, Nikita Subedi, Nicole van Buuringen, Daan Heister, Judith Vivié, Inge Beeren-Reinieren, Rob Woestenenk, Harry Dolstra, Aigars Piruska, Joannes F. M. Jacobs, Alexander van Oudenaarden, Carl G. Figdor, Wilhelm T. S. Huck, I. Jolanda M. de Vries, Jurjen Tel
Published 2018-08-01

Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity

by Vanessa Almendro, Yu-Kang Cheng, Amanda Randles, Shalev Itzkovitz, Andriy Marusyk, Elisabet Ametller, Xavier Gonzalez-Farre, Montse Muñoz, Hege G. Russnes, Åslaug Helland, Inga H. Rye, Anne-Lise Borresen-Dale, Reo Maruyama, Alexander van Oudenaarden, Mitchell Dowsett, Robin L. Jones, Jorge Reis-Filho, Pere Gascon, Mithat Gönen, Franziska Michor, Kornelia Polyak
Published 2014-02-01

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

by Hessel Honkoop, Dennis EM de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D Nguyen, Cecilia de Heus, Laurence Garric, Mauro J Muraro, Adam Shoffner, Federico Tessadori, Joshua Craiger Peterson, Wendy Noort, Alberto Bertozzi, Gilbert Weidinger, George Posthuma, Dominic Grün, Willem J van der Laarse, Judith Klumperman, Richard T Jaspers, Kenneth D Poss, Alexander van Oudenaarden, Eldad Tzahor, Jeroen Bakkers
Published 2019-12-01