Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

by Alexandra J. Corbett, Wael Awad, Wael Awad, Huimeng Wang, Huimeng Wang, Zhenjun Chen
Published 2020-08-01

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

by Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn
Published 2016-08-01

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

by Jeffrey Y. W. Mak, Weijun Xu, Robert C. Reid, Alexandra J. Corbett, Bronwyn S. Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P. Fairlie
Published 2017-03-01

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

by Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey
Published 2019-09-01

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets

by Ayako Kurioka, Aminu S. Jahun, Rachel F. Hannaway, Lucy J. Walker, Joannah R. Fergusson, Eva Sverremark-Ekström, Alexandra J. Corbett, James E. Ussher, Christian B. Willberg, Christian B. Willberg, Paul Klenerman, Paul Klenerman
Published 2017-08-01

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

by Zhongfang Wang, Xiaoyun Yang, Jiaying Zhong, Yumin Zhou, Zhiqiang Tang, Haibo Zhou, Jun He, Xinyue Mei, Yonghong Tang, Bijia Lin, Zhenjun Chen, James McCluskey, Ji Yang, Alexandra J. Corbett, Pixin Ran
Published 2021-03-01

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

by Amine Toubal, Badr Kiaf, Lucie Beaudoin, Lucie Cagninacci, Moez Rhimi, Blandine Fruchet, Jennifer da Silva, Alexandra J. Corbett, Yannick Simoni, Olivier Lantz, Jamie Rossjohn, James McCluskey, Philippe Lesnik, Emmanuelle Maguin, Agnès Lehuen
Published 2020-07-01

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobi...

by Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, S M Mansour Haeryfar
Published 2017-06-01

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

by Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S. Meehan, Adam G. Nelson, David P. Fairlie, Jeffrey Y. W. Mak, Sidonia B. G. Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G. Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett, Zhenjun Chen
Published 2021-07-01

MAIT cells contribute to protection against lethal influenza infection in vivo

by Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J. Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nüssing, Sneha Sant, Zhongfang Wang, Criselle D’Souza, Xiaoxiao Jia, Catarina F. Almeida, Lyudmila Kostenko, Sidonia B. G. Eckle, Bronwyn S. Meehan, Axel Kallies, Dale I. Godfrey, Patrick C. Reading, Alexandra J. Corbett, James McCluskey, Paul Klenerman, Katherine Kedzierska, Timothy S. C. Hinks
Published 2018-11-01

MAIT cells protect against pulmonary Legionella longbeachae infection

by Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J. Pediongco, Sidonia B. G. Eckle, Bronwyn S. Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey Y. W. Mak, David P. Fairlie, Yoichiro Iwakura, Jennifer M. Gunnersen, Andrew W. Stent, Dale I. Godfrey, Jamie Rossjohn, Glen P. Westall, Lars Kjer-Nielsen, Richard A. Strugnell, James McCluskey, Alexandra J. Corbett, Timothy S. C. Hinks, Zhenjun Chen
Published 2018-08-01